{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:32:43Z","timestamp":1773005563196,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW001140"],"award-info":[{"award-number":["D43TW001140"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neurocysticercosis is a leading cause of acquired epilepsy in endemic regions. Scarce longitudinal data sets exist to allow assessment of secular trends in prevalence. This study analysed temporal trends of cysticercosis seropositivity among suspected patients across Peru over two decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An ecological study was conducted using anonymized serological data from patients who underwent enzyme\u2010linked immunoelectrotransfer blot (EITB) testing for the first time at a neurological referral centre in Lima, Peru. Seropositivity was defined as antibody reactivity to \u2265\u20091 glycoprotein band, and higher thresholds (\u2265\u20093, \u2265\u20094 bands) were also assessed considering their association with active disease. Temporal trends were analysed using generalised linear models with Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 39,481 individuals, seropositivity was 31.3% (12,350\/39,481). The prevalence of seropositivity increased from 27.3% in the initial 5\u2010year period (2000\u20132004) to 37.4% in the last (2014\u20132019), while the numbers of requested tests decreased from 15,074 to 5130 and the overall numbers of new seropositive individuals decreased from 4109 cases to 1918. High\u2010reactivity cases also increased in proportion but decreased in number (\u2265\u20093 bands: 18.1% to 27.1% and 2734 to 1392; \u2265\u20094 bands: 7.9% to 17.5% and 1194 to 897), suggesting a greater proportion of active or clinically relevant infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over 20\u2009years, the demand for cysticercosis serology and the numbers of seropositive cases by 5\u2010year periods decreased while the proportion of seropositive cases rose significantly within a single specialised referral centre. While data from suspected clinical cases do not necessarily represent disease burden at the population level, the reduction in case numbers may represent reduced disease prevalence. At the same time, the persistence of significant numbers of cases in this single centre study through the last examined period and the increased proportion of strong seropositive cases demonstrate that cysticercosis is still endemic in Peru.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70080","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:11:06Z","timestamp":1768824666000},"page":"390-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Study of Frequency and Secular Trends of Seropositivity for Cysticercosis in Peru Over 20\u2009Years"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-8382","authenticated-orcid":false,"given":"S. Mathof","family":"Salas","sequence":"first","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cilene","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Toledo","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz M.","family":"Toribio","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia  Lima Peru"},{"name":"Infection and Immunity Institute, St George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia  Lima Peru"},{"name":"Research and Development Laboratories, Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n (CBI) en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso (Laboratorio de Cisticercosis) \u2013 Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia  Lima Peru"},{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Research and Development Laboratories, Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Cysticercosis Working Group in Peru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000870"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001500"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-39022-7_2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.07.003"},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization \u201cEnding the Neglect to Attain the Sustainable Development Goals: A Road Map for Neglected Tropical Diseases 2021\u20132030 \u201d in (World Health Organization) https:\/\/www.who.int\/publications\/i\/item\/9789240010352."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2349"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003919"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/2047773212Y.0000000048"},{"key":"e_1_2_9_10_1","article-title":"Immunodiagnosis of Neurocysticercosis: Ways to Focus on the Challenge","volume":"2011","author":"Esquivel\u2010Vel\u00e1zquez M.","year":"2011","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.1.50"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix774"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03260-13"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13010026"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.10.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005130"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/313470"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2023.402.12472"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576205500326"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010652"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:08:50Z","timestamp":1772996930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/tmi.70080"],"URL":"https:\/\/doi.org\/10.1111\/tmi.70080","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}