{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:52:33Z","timestamp":1777956753805,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In southern Thailand, the low efficacy of albendazole contributes to the unsuccessful elimination of hookworms. Individuals infected with hookworms exhibiting low albendazole efficacy show decreased mean corpuscular volume and mean corpuscular haemoglobin and are suspected carriers of abnormal haemoglobin. This observational study aimed to compare the treatment outcomes of albendazole for hookworm infection in individuals with normal versus abnormal haemoglobin types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>227 stool samples were examined using the Kato\u2010Katz and agar plate culture methods. Blood samples were collected from participants with hookworm\u2010positive stool after oral administration of 400\u2009mg albendazole to perform complete blood counts and haemoglobin typing. Treatment outcomes were evaluated 3\u2009weeks after albendazole administration. Participants with persistent hookworm infection received a second 400\u2009mg dose of albendazole, and outcomes were reassessed 3\u2009weeks later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 54 hookworm\u2010positive participants, 38 were cured after the first round of treatment, and 5 were cured after the second round, all of whom had normal haemoglobin. However, 11 participants remained uncured after two treatment rounds, all with abnormal haemoglobin types: 7 with heterozygous haemoglobin E, 3 with heterozygous haemoglobin constant spring (CS) and 1 with compound heterozygous haemoglobin E\/CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that abnormal haemoglobin may be a host factor contributing to low albendazole efficacy in treating hookworm infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70093","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:43:24Z","timestamp":1770119004000},"page":"589-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poor Response to Albendazole in Hookworm\u2010Infected Abnormal Haemoglobin Carriers"],"prefix":"10.1111","volume":"31","author":[{"given":"Attarat","family":"Pattanawongsa","sequence":"first","affiliation":[{"name":"School of Pharmacy Walailak University  Nakhon Si Thammarat Thailand"},{"name":"Drug and Cosmetics Excellence Center Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manit","family":"Nuinoon","sequence":"additional","affiliation":[{"name":"School of Allied Health Sciences Walailak University  Nakhon Si Thammarat Thailand"},{"name":"Hematology and Transfusion Science Research Center Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasit","family":"Na\u2010ek","sequence":"additional","affiliation":[{"name":"Department of Medical Science, School of Medicine Walailak University  Nakhon Si Thammarat Thailand"},{"name":"Research Center in Tropical Pathobiology Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-8275","authenticated-orcid":false,"given":"Patthanasak","family":"Khammaneechan","sequence":"additional","affiliation":[{"name":"School of Public Health Walailak University  Nakhon Si Thammarat Thailand"},{"name":"EC for PHR Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blego","family":"Sedionoto","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Faculty of Public Health Mulawarman University  Samarinda Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1509-4046","authenticated-orcid":false,"given":"Witthaya","family":"Anamnart","sequence":"additional","affiliation":[{"name":"School of Allied Health Sciences Walailak University  Nakhon Si Thammarat Thailand"},{"name":"School of Public Health Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8885734"},{"key":"e_1_2_10_3_1","volume-title":"License: CC BY\u2010NC\u2010SA 3.0 IGO","author":"Anonymous World Health Organization","year":"2017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0948"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272821"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0682"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2013.51.6.747"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.88"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001417"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(12)60125-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0171-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3296-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2010.08.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630261003680191"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1762"},{"key":"e_1_2_10_16_1","first-page":"498","article-title":"Hemoglobinopathies in Southeast Asia","volume":"134","author":"Fucharoen S.","year":"2011","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012331"},{"key":"e_1_2_10_18_1","unstructured":"K.IadnimitandS.Denduang \u201cPrevalence of Albendazole Ineffective Hookworm in Community of Moklalan Subdistrict of Nakhon Si Thammarat. 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