{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:52:37Z","timestamp":1777956757034,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aims to evaluate the diagnostic accuracy of various point\u2010of\u2010care devices for detecting deficiency of glucose\u20106\u2010phosphate dehydrogenase among malaria patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed. Data extracted include the number of true positives, false negatives, false positives and true negatives to calculate sensitivity and specificity for various devices. CareStart G6PD rapid diagnostic test and the STANDARD G6PD Biosensor were assessed against spectrophotometry (gold standard) at clinically relevant activity thresholds of 30% and 70%. Pooled estimates were generated using a random\u2010effects model in R (version 4.3.1). Risk of bias was assessed using the QUADAS\u20102 tool. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database with reference ID CRD420251122222.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13 cross\u2010sectional studies were included. At the 30% threshold the pooled sensitivity of CareStart was 0.82 (95% CI: 0.55\u20130.95) and specificity was 0.96 (95% CI: 0.93\u20130.98). At a 70% threshold the pooled sensitivity of CareStart was 0.54 (95% CI: 0.31\u20130.76), although specificity remained high at 0.96 (95% CI: 0.84\u20130.99). For the STANDARD G6PD Biosensor, the pooled sensitivity at 30% and 70% was 0.99 (95% CI: 0.96\u20131.00) and 0.96 (95% CI: 0.90\u20130.98), respectively, while the pooled specificity values for the above thresholds were 0.98 (95% CI: 0.97\u20130.99) and 0.96 (95% CI: 0.89\u20130.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quantitative point\u2010of\u2010care testing using STANDARD G6PD Biosensor demonstrates superior diagnostic performance, particularly for identifying intermediate G6PD activity, supporting its preferential use for guiding safe radical cure with 8\u2010aminoquinoline therapies in malaria\u2010endemic settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70108","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:42:15Z","timestamp":1772991735000},"page":"643-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of Point\u2010of\u2010Care Devices for Glucose\u20106\u2010Phosphate Dehydrogenase Deficiency Detection Among Malaria Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Greeshma","family":"Unnikrishnan","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-9955","authenticated-orcid":false,"given":"Abhinav","family":"Singh","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cWorld Malaria Report 2023 \u201daccessed October 5 2025 https:\/\/www.who.int\/teams\/global\u2010malaria\u2010programme\/reports\/world\u2010malaria\u2010report\u20102023."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196716"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1098828"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001339"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802537"},{"key":"e_1_2_10_8_1","volume-title":"WHO Guidelines for Malaria","author":"World Health Organization","year":"2023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-024-05144-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002992"},{"key":"e_1_2_10_11_1","unstructured":"\u201cRayyan: AI\u2010Powered Systematic Review Management Platform \u201dhttps:\/\/www.rayyan.ai\/."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-023-04559-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206331"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2390-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257560"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301506"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004457"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2022.60.4.281"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0552"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116143"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009649"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0100"},{"issue":"10","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"e0009720","DOI":"10.1371\/journal.pntd.0009720","article-title":"Prevalence of Glucose\u20106\u2010Phosphate Dehydrogenase Deficiency, CareStart Qualitative Rapid Diagnostic Test Performance, and Genetic Variants in Two Malaria\u2010Endemic Areas in Sudan","volume":"15","author":"Albsheer M. 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