{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:16:31Z","timestamp":1783113391712,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1126780"],"award-info":[{"award-number":["OPP1126780"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Serious bacterial infections (SBIs) are major contributors to neonatal morbidity and mortality in low\u2010income countries. We describe the aetiology and risk factors for neonatal bacteraemia and in\u2010hospital mortality in eastern Ethiopia, focusing on\n \n Pantoea dispersa<\/jats:styled-content>\n ,\n <\/jats:italic>\n a rarely studied pathogen, and\n \n Klebsiella pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective surveillance was conducted at Hiwot Fana Comprehensive Specialized Hospital (HFCSH), Harar, from December 2021 to November 2023. Blood for culture was drawn from neonates admitted with the WHO clinical definition of possible\u2010SBI (pSBI). Isolates were identified using API kits and antimicrobial susceptibility tested by Kirby\u2010Bauer method.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n Among 1375 neonates with pSBI, blood was cultured from 1335 (97%), and 356 (27%) cultured pathogens. The commonest infections were\n Pantoea<\/jats:italic>\n species (\n n<\/jats:italic>\n \u2009=\u2009145, 40.7%) and\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u200963, 17.7%); 128\n Pantoea<\/jats:italic>\n isolates were identified as\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n by Matrix\u2010Assisted Laser Desorption Ionization\u2010Time of Flight. Case\u2010fatality\u2010ratios were 25% (32\/128), 19% (9\/47) and 19% (30\/160) for\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n and other monomicrobial infections, respectively.\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n showed resistance to ampicillin (99%) and cefotaxime (85%) but was otherwise broadly susceptible, while\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n showed resistance to cefotaxime (100%) and gentamicin (89%), remaining susceptible only to amikacin and meropenem. Compared to non\u2010bacteraemic admissions,\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n bacteraemia was associated with health\u2010facility delivery outside HFCSH (aOR 1.9 [95% CI, 1.21\u20132.97]), low birth weight (aOR 2.1 [95% CI,1.22\u20133.47]), and the dry season (aOR 9.7, [95% CI, 4.61\u201320.31]).\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n bacteraemia was associated with health\u2010facility delivery outside HFCSH (aOR, 2.2, [95% CI, 1.09\u20134.27]) alone. Among admissions with pSBI, death was associated with low birth weight and\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n bacteraemia.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n Bacteraemia was prevalent among neonates admitted with pSBI to HFCSH.\n P. dispersa<\/jats:italic>\n and\n \n K. pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n predominated and both had high mortality risks\n .<\/jats:italic>\n Rigorous diagnostics and epidemiological associations support the interpretation of\n \n P. dispersa<\/jats:italic>\n <\/jats:styled-content>\n as a pathogen, necessitating local investigation into transmission and infection control interventions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.70140","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:24:41Z","timestamp":1776839081000},"page":"933-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serious Bacterial Infections in Hospitalized Neonates in Eastern Ethiopia: Investigating the Emerging Pathogen\n \n Pantoea dispersa<\/i>\n <\/scp>\n Compared With\n \n Klebsiella pneumoniae<\/i>\n <\/scp>"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-8109","authenticated-orcid":false,"given":"Yunus","family":"Edris","sequence":"first","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"},{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisel A.","family":"Hassen","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-7492","authenticated-orcid":false,"given":"Desalegn A.","family":"Ayana","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fami","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleluya","family":"Leulseged","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"},{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadi","family":"Marami","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabir","family":"Aliye","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belete G.","family":"Alem","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelalem T.","family":"Mariam","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gezahang","family":"Mengesha","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-2329","authenticated-orcid":false,"given":"Nega","family":"Assefa","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"},{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Aiken","sequence":"additional","affiliation":[{"name":"Haramaya University College of Health and Medical Sciences Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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