{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:13:15Z","timestamp":1788315195833,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the epidemiological characteristics, spatial distribution and predictors of TB\u2010related mortality in Risaralda from 2020 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted using secondary data from the National Public Health Surveillance System (SIVIGILA). Descriptive statistics, spatial analysis (choropleth maps) and binary logistic regression were used to identify sociodemographic and clinical factors associated with TB case fatality. Model performance was evaluated using ROC curves, sensitivity, specificity and 5\u2010fold cross\u2010validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2081 confirmed TB cases were analysed, with a case fatality rate of 13.2%. Mortality was higher among individuals \u2265\u200965\u2009years (OR: 3.87), hospitalized patients (OR: 7.33), HIV\u2010positive individuals (OR: 3.49), those with undernutrition (OR: 1.89), males (OR: 1.45) and Indigenous persons (OR: 1.67). The logistic model showed good discrimination (AUC: 0.82), with sensitivity of 79.2% and specificity of 73.8%. Cross\u2010validation confirmed model stability (AUC: 0.81). Spatial analysis revealed high mortality in rural municipalities with low case burden, suggesting health inequities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TB mortality in Risaralda is influenced by age, comorbidities and social determinants, with pronounced territorial disparities. These findings support the integration of spatial and predictive tools in TB surveillance to strengthen targeted interventions and reduce mortality in high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70168","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:29:38Z","timestamp":1779182978000},"page":"1284-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological, Spatial and Predictive Analysis of Tuberculosis\u2010Related Mortality in the Department of Risaralda (Colombia), 2020\u20132024"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-0980","authenticated-orcid":false,"given":"Brayan Esneider","family":"Pati\u00f1o\u2010Palma","sequence":"first","affiliation":[{"name":"ZIPATEFI Research Group Fundaci\u00f3n Universitaria del \u00c1rea Andina  Pereira Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2196-8190","authenticated-orcid":false,"given":"Sandra Yineth","family":"Chac\u00f3n\u2010Bambague","sequence":"additional","affiliation":[{"name":"ZIPATEFI Research Group Fundaci\u00f3n Universitaria del \u00c1rea Andina  Pereira Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhlyn Paola","family":"Bermudez\u2010Moreno","sequence":"additional","affiliation":[{"name":"GIER Research Group Fundaci\u00f3n Universitaria del \u00c1rea Andina  Pereira Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization \u201cGlobal Tuberculosis Report 2023 \u201d2023 WHO https:\/\/www.who.int\/teams\/global\u2010programme\u2010on\u2010tuberculosis\u2010and\u2010lung\u2010health\/tb\u2010reports\/global\u2010tuberculosis\u2010report\u20102023."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2020.153"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization \u201cGlobal Tuberculosis Report 2024 \u201d2024 WHO https:\/\/www.who.int\/teams\/global\u2010programme\u2010on\u2010tuberculosis\u2010and\u2010lung\u2010health\/tb\u2010reports\/global\u2010tuberculosis\u2010report\u20102024."},{"key":"e_1_2_9_5_1","unstructured":"Instituto Nacional de Salud \u201cInforme de evento Tuberculosis. 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