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In 2024, Brazil experienced its largest recorded dengue epidemic, with intense transmission across the Northeast region. This study characterizes the epidemiological, genomic and phylogeographic features of dengue virus (DENV) circulation during the 2024 outbreak in Alagoas, northeastern Brazil. Of 6102 suspected cases analysed by molecular diagnostics, 1607 (26.3%) were confirmed as DENV infections. Epidemiological analyses revealed widespread transmission across 79 municipalities, marked seasonality with peak incidence between March and August, and a disproportionate burden among adolescents and young adults. DENV\u20101 and DENV\u20102 were the predominant serotypes, accounting for 57.1% and 42.6% of confirmed cases, respectively; three DENV\u20103 infections and one DENV\u20101\/DENV\u20102 co\u2010infection were also identified. Whole\u2010genome sequencing yielded high\u2010quality genomic data supporting phylogenetic and phylogeographic analyses. 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Collectively, these findings indicate that the 2024 outbreak was driven by recurrent viral introductions combined with the persistence of locally established transmission chains, highlighting the value of integrated genomic surveillance for outbreak preparedness and public health response.<\/jats:p>","DOI":"10.1111\/tmi.70189","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:51:46Z","timestamp":1782294706000},"page":"1419-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic Surveillance of Dengue Virus During the 2024 Outbreak in a Northeastern Brazilian State"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-4871","authenticated-orcid":false,"given":"Jean Phellipe Marques","family":"do Nascimento","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica de Alagoas (LACEN\u2010AL), Setor 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