{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:59:02Z","timestamp":1790848742253,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilia is a common clinical finding with diverse etiologies. Helminthiasis is a major aetiology in tropical regions, but data from haematology consultation services at tertiary centres in endemic settings are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of helminthiasis among patients with eosinophilia at a tropical tertiary care centre and identify clinical and laboratory characteristics differentiating helminth from non\u2010helminth etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study with predefined retrospective outcome classification was conducted at Siriraj Hospital, Thailand (January 2022 to November 2023) in adult patients with blood eosinophilia above 500 cells\/\u03bcL. All patients underwent helminth screening through stool examination and serological testing for strongyloidiasis, gnathostomiasis, angiostrongyliasis, filariasis and cysticercosis, and received empirical ivermectin or albendazole with monthly follow\u2010up for 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 131 patients, 76 (58.0%) were diagnosed with helminthiasis, comprising 49 definite (laboratory\u2010confirmed) and 27 probable (treatment\u2010response\u2010defined) infections. Strongyloidiasis (53.1%) was most common among definite infections, followed by gnathostomiasis (40.8%) and cysticercosis (26.5%), with multiple infections in 24.5% of definite cases. The median time to absolute eosinophil count (AEC) normalization was 1.0\u2009month (IQR: 1.0\u20132.0), with 93.4% normalizing within 3\u2009months. Probable infections were significantly associated with soil contact and forest travel (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while definite infections were associated with organism\u2010specific exposures (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Patients aged 75\u2009years or above showed significantly lower AEC at presentation (adjusted geometric mean ratio 0.52, 95% CI: 0.31\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Leukopenia and hypoalbuminemia were more prevalent in non\u2010infectious etiologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Helminthiasis was identified in more than half of patients with eosinophilia at a tropical tertiary haematology service. Empirical anthelmintic therapy effectively normalized eosinophilia in the majority within 3\u2009months, supporting its use as a standard initial approach in endemic settings. Detailed exposure anamnesis and concurrent evaluation for non\u2010helminth etiologies, particularly in patients with leukopenia or hypoalbuminemia, should be routinely performed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70191","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:30:03Z","timestamp":1782696603000},"page":"1433-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilia in the Tropics: Should Empirical Anthelmintic Treatment Be Considered Standard Practice? A Prospective Cohort Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Smith","family":"Kungwankiattichai","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Center of Excellence of Siriraj Adult Acute Myeloid\/Lymphoblastic Leukemia (SiAML), Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsharaporn T.","family":"Sarasombath","sequence":"additional","affiliation":[{"name":"Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattaraporn","family":"Tunsing","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2005","authenticated-orcid":false,"given":"Weerapat","family":"Owattanapanich","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Center of Excellence of Siriraj Adult Acute Myeloid\/Lymphoblastic Leukemia (SiAML), Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14488"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1193730"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12955"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.11.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.05.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012049"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.702"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.08.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2017.09.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0853"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/522529"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(91)90079-M"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"624","article-title":"Detection of Circulating Antigens of Parastrongylus Cantonensis in Human Sera by Dot\u2010Blot ELISA and Sandwich ELISA Using Monoclonal Antibody","volume":"28","author":"Eamsobhana P.","year":"1997","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"308","article-title":"Purification of a Specific Immunodiagnostic Parastrongylus Cantonensis Antigen by Electroelution From SDS\u2010Polyacrylamide Gels","volume":"32","author":"Eamsobhana P.","year":"2001","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2012.0971"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X14000522"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27287"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2022.09.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R"},{"issue":"4","key":"e_1_2_10_21_1","first-page":"829","article-title":"Integrated Histological and Molecular Analysis of Filarial Species and Associated Wolbachia Endosymbionts in Human Filariasis Cases Presenting Atypically in Thailand","volume":"111","author":"Sarasombath P. 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