{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:00:48Z","timestamp":1785394848827,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to assess the clinical characteristics and outcomes of mpox and mpox\u2013\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      coinfection in Lima, Peru, during the 2022\u20132023 outbreak. Also, it sought to identify predictors of hospitalisation, particularly related to\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      immunosuppression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of 588 individuals with confirmed mpox across three public referral hospitals in Lima, Peru, between June 2022 and January 2023. Data were extracted from mpox surveillance forms, medical charts, and laboratory systems. Descriptive statistics and bivariate analyses were performed, followed by multivariate logistic regression to identify predictors of hospitalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 588 individuals with mpox, the mean age was 32.1\u2009years, and 54.8% were people living with HIV (PLWH). Hospitalisation occurred in 8% of individuals, with a higher rate among PLWH (11.2%) compared to individuals without HIV (4.1%). Proctitis and a CD4 count &lt;\u2009500 cells\/\u03bcL were significant predictors of hospitalisation (adjusted odds ratio [aOR]: 7.47 and 5.74, respectively). Lesion counts were lower in PLWH, and a distinct rash distribution was observed. Six deaths occurred, all in PLWH, with sepsis being the leading cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the clinical differences of mpox between PLWH and people without HIV in Lima, with even mild HIV\u2010related immunosuppression (CD4\u2009&lt;\u2009500 cells\/\u03bcL) and proctitis being key factors for hospitalisation. Deaths occurred exclusively in PLWH, emphasising the importance of managing HIV effectively to mitigate severe mpox outcomes. Strengthening HIV care and ensuring access to mpox treatment are critical in response strategies for future outbreaks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70209","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:35:10Z","timestamp":1785393310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Mpox and Mpox\u2013\n                    <scp>HIV<\/scp>\n                    Coinfection in Lima, Peru: A Retrospective Multicenter Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-3808","authenticated-orcid":false,"given":"Neil","family":"Rupani","sequence":"first","affiliation":[{"name":"Morsani College of Medicine University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Per\u00fa  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Per\u00fa  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frine","family":"Samalvides","sequence":"additional","affiliation":[{"name":"Hospital Nacional Cayetano Heredia  Lima Peru"},{"name":"Facultad de Medicina Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Hospital Nacional Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Miranda","sequence":"additional","affiliation":[{"name":"Hospital de Emergencias de Villa El Salvador  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Hospital Nacional Sergio E. Bernales  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Orellana","sequence":"additional","affiliation":[{"name":"Facultad de Salud P\u00fablica y Administraci\u00f3n Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Mitnick","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine Harvard Medical School  Boston USA"},{"name":"Division of Infectious Diseases Brigham and Women's Hospital  Boston USA"},{"name":"Partners in Health  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly F.","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine Harvard Medical School  Boston USA"},{"name":"Harvard T.H. Chan School of Public Health  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-0036","authenticated-orcid":false,"given":"Renato A.","family":"Errea","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Per\u00fa  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003748"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2237-96222022000300036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.102494"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00273-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2024.102701"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/epidemiologia4030033"},{"key":"e_1_2_9_8_1","unstructured":"UNAIDS \u201cPeru \u201d2025 [Internet] https:\/\/www.unaids.org\/en\/regionscountries\/countries\/peru."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.01.045"},{"key":"e_1_2_9_10_1","unstructured":"World Health Organization (WHO) \u201cMulti\u2010Country Outbreak of Mpox \u201d2024 cited May 11 2025 [Internet] https:\/\/www.who.int\/docs\/default\u2010source\/coronaviruse\/situation\u2010reports\/20240812_mpox_external\u2010sitrep_35.pdf#:~:text=%E2%80%A2%20As%20reporting%20from%20countries 2024%2C%20with%20a%20positivity%20of."},{"issue":"10","key":"e_1_2_9_11_1","first-page":"204993612311966","article-title":"Hospitalization Risk Among Patients With Mpox Infection\u2014A Propensity Score Matched Analysis","volume":"30","author":"Henao\u2010Mart\u00ednez A. F.","year":"2023","journal-title":"Therapeutic Advances in Infectious Disease"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad482"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00651-X"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:35:14Z","timestamp":1785393314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":12,"alternative-id":["10.1111\/tmi.70209"],"URL":"https:\/\/doi.org\/10.1111\/tmi.70209","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2025-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"tmi.70209"}}