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Individuals infected with\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    carrying deletions of the\n                    <jats:italic>pfhrp2\/3<\/jats:italic>\n                    genes may yield false\u2010negative results in Rapid Diagnostic Tests (RDTs) based on the detection of these antigens. A total of 342 samples from symptomatic individuals infected with\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    , collected during epidemiological surveillance activities in the municipalities of the international frontier between Brazil and Peru and between Brazil and Venezuela were analysed. Of the 342 samples evaluated, 86 (25.2%) showed\n                    <jats:italic>pfhrp<\/jats:italic>\n                    2\u2010deletion, 32 (9.4%) double deletions of the\n                    <jats:italic>pfhrp2\/3<\/jats:italic>\n                    genes, and 168 (49.1%) had a single deletion of the\n                    <jats:italic>pfhrp3<\/jats:italic>\n                    gene. The frequency of parasites with\n                    <jats:italic>pfhrp2\/3<\/jats:italic>\n                    deletions highlights the importance of genomic surveillance in international border areas, alongside the evaluation of the effectiveness of RDTs used in the country.\n                  <\/jats:p>","DOI":"10.1111\/tmi.70221","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:54:51Z","timestamp":1788958491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Plasmodium falciparum<\/i>\n                    Parasites With Histidine\u2010Rich Protein 2 (\n                    <i>pfhrp2<\/i>\n                    ) and\n                    <i>pfhrp3<\/i>\n                    Gene Deletions in Frontier Endemic Regions of Brazilian Amazon"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5546-3323","authenticated-orcid":false,"given":"J\u00e9ssica","family":"de Oliveira Bonsanto Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Graduate Program in Tropical Medicine Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"},{"name":"Laboratory of Parasitic Diseases Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"da Silva Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-6901","authenticated-orcid":false,"given":"Rodrigo Medeiros","family":"Martorano","sequence":"additional","affiliation":[{"name":"Federal University of Acre\/UFAC, Campus Floresta  Cruzeiro do Sul\u00b8Acre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Louzada","sequence":"additional","affiliation":[{"name":"Federal University of Roraima\/UFRR  Boa\u2010Vista Roraima Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9908-2660","authenticated-orcid":false,"given":"Victoria Martins Roque","family":"Almeida","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Medicine Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"},{"name":"Laboratory of Parasitic Diseases Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Rego","family":"Viana","sequence":"additional","affiliation":[{"name":"Federal Institute of Esp\u00edrito Santo\/IFES  Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josely Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Imunoparasitology Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anielle Pina","family":"Costa","sequence":"additional","affiliation":[{"name":"Infectiology National Institute, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-0294","authenticated-orcid":false,"given":"Andr\u00e9","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Infectiology National Institute, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Cec\u00edlia","family":"Su\u00e1rez\u2010Mutis","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Medicine Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"},{"name":"Laboratory of Parasitic Diseases Institute Oswaldo Cruz, Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"14","key":"e_1_2_11_2_1","first-page":"1","article-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade e Ambiente","volume":"55","author":"Brasil. 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