{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:37:25Z","timestamp":1791110245788,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Summary<\/jats:title>The role of A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic>, an R<\/jats:styled-content>2R<\/jats:styled-content>3 MYB<\/jats:styled-content> transcription factor, in signaling mediated by jasmonic acid (JA<\/jats:styled-content>) and salicylic acid (SA<\/jats:styled-content>) is examined. A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> is induced by JA<\/jats:styled-content> through CORONATINE INSENSITIVE<\/jats:styled-content>\u00a01 (COI<\/jats:styled-content>1). A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> over\u2010expression down\u2010regulated defense responses against the necrotrophic pathogen A<\/jats:styled-content>lternaria brassicicola<\/jats:italic>, but up\u2010regulated WRKY<\/jats:styled-content>70<\/jats:italic> and PR<\/jats:italic><\/jats:styled-content> genes, leading to enhanced resistance to the biotrophic pathogen P<\/jats:styled-content>seudomonas syringae<\/jats:italic> pv. tomato <\/jats:italic>DC<\/jats:styled-content>3000. The knockout mutant atmyb44<\/jats:italic> shows opposite effects. Induction of WRKY<\/jats:styled-content>70<\/jats:italic> by SA<\/jats:styled-content> is reduced in atmyb44<\/jats:italic> and npr1<\/jats:italic>\u20101<\/jats:italic> mutants, and is totally abolished in atmyb44 npr1<\/jats:italic>\u20101<\/jats:italic> double mutants, showing that WRKY<\/jats:styled-content>70<\/jats:italic> is regulated independently through both NPR<\/jats:styled-content>1<\/jats:italic> and A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic>. AtMYB<\/jats:styled-content>44<\/jats:italic> over\u2010expression does not change SA<\/jats:styled-content> content, but A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> over\u2010expression phenotypes, such as retarded growth, up\u2010regulated PR<\/jats:styled-content>1<\/jats:italic> and down\u2010regulated PDF<\/jats:styled-content>1.2<\/jats:italic> are reversed by SA<\/jats:styled-content> depletion. The wrky70<\/jats:italic> mutation suppressed AtMYB<\/jats:styled-content>44<\/jats:italic> over\u2010expression phenotypes, including up\u2010regulation of PR<\/jats:styled-content>1<\/jats:italic> expression and down\u2010regulation of PDF<\/jats:styled-content>1.2<\/jats:italic> expression. \u03b2\u2010estradiol\u2010induced expression of A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> led to WRKY<\/jats:styled-content>70<\/jats:italic> activation and thus PR<\/jats:styled-content>1<\/jats:italic> activation. A<\/jats:styled-content>tMYB<\/jats:styled-content>44 binds to the WRKY<\/jats:styled-content>70<\/jats:italic> promoter region, indicating that A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> acts as a transcriptional activator of WRKY<\/jats:styled-content>70<\/jats:italic> by directly binding to a conserved sequence element in the WRKY<\/jats:styled-content>70<\/jats:italic> promoter. These results demonstrate that A<\/jats:styled-content>tMYB<\/jats:styled-content>44<\/jats:italic> modulates antagonistic interaction by activating SA<\/jats:styled-content>\u2010mediated defenses and repressing JA<\/jats:styled-content>\u2010mediated defenses through direct control of WRKY<\/jats:styled-content>70<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/tpj.12051","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T17:24:55Z","timestamp":1350321895000},"page":"483-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["A<\/scp>tMYB<\/scp>44<\/i> regulates WRKY<\/scp>70<\/i> expression and modulates antagonistic interaction between salicylic acid and jasmonic acid signaling"],"prefix":"10.1111","volume":"73","author":[{"given":"Jae Sung","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choonkyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangjoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghun","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonhee","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seob","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Tae","family":"Song","sequence":"additional","affiliation":[{"name":"School of Applied Biosciences Kyungpook National University Daegu 702\u2010701 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Kon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Bioscience and Bioinformatics Myongi University Yongin 449\u2010728 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Do","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Seoul National University Seoul 151\u2010921 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1573","article-title":"The cpr5 mutant of Arabidopsis expresses both NPR1\u2010dependent and NPR1\u2010independent resistance","volume":"9","author":"Bowling S.A.","year":"1997","journal-title":"Plant Cell"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.115683"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81858-9"},{"key":"e_1_2_6_5_1","first-page":"85","article-title":"Preparation of RNA","volume":"82","author":"Carpenter C.D.","year":"1998","journal-title":"Methods Mol. 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