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Although the abiotic stress\u2010responsive pathway interacts antagonistically with the biotic stress\u2010responsive pathways, the mechanisms that regulate these pathways remain largely unknown. In this study, we provide insight into the function of vascular plant one\u2010zinc\u2010finger proteins (<jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>s) that modulate various stress responses in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rabidopsis. The expression of many stress\u2010responsive genes was changed in the <jats:italic>voz1voz2<\/jats:italic> double mutant under normal growth conditions. Consistent with altered stress\u2010responsive gene expression, freezing\u2010 and drought\u2010stress tolerances were increased in the <jats:styled-content style=\"fixed-case\"><jats:italic>voz1voz2<\/jats:italic><\/jats:styled-content> double mutant. In contrast, resistance to a fungal pathogen, <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>olletotrichum higginsianum<\/jats:italic>, and to a bacterial pathogen, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas syringae<\/jats:italic>, was severely impaired. Thus, impairing <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content> function simultaneously conferred increased abiotic tolerance and biotic stress susceptibility. In a chilling stress condition, both the <jats:styled-content style=\"fixed-case\"><jats:italic>VOZ1<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>VOZ2<\/jats:italic><\/jats:styled-content> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression levels and the <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>2 protein level gradually decreased. <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>2 degradation during cold exposure was completely inhibited by the addition of the 26<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> proteasome inhibitor, <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>132, a finding that suggested that <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>2 degradation is dependent on the ubiquitin\/26<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> proteasome system. In <jats:styled-content style=\"fixed-case\"><jats:italic>voz1voz2<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ABA<\/jats:styled-content>\u2010inducible transcription factor <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>4 expression was enhanced significantly even under normal growth conditions, despite an unchanged endogenous <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content> content. A finding that suggested that <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>s negatively affect <jats:styled-content style=\"fixed-case\"><jats:italic>CBF4<\/jats:italic><\/jats:styled-content> expression in an <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>\u2010independent manner. These results suggest that <jats:styled-content style=\"fixed-case\">VOZ<\/jats:styled-content>s function as both negative and positive regulators of the abiotic and biotic stress\u2010responsive pathways, and control Arabidopsis adaptation to various stress conditions.<\/jats:p>","DOI":"10.1111\/tpj.12069","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T08:26:52Z","timestamp":1353486412000},"page":"761-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Vascular plant one\u2010zinc\u2010finger protein 1\/2 transcription factors regulate abiotic and biotic stress responses in Arabidopsis"],"prefix":"10.1111","volume":"73","author":[{"given":"Yusuke","family":"Nakai","sequence":"first","affiliation":[{"name":"Graduate School of Life and Environmental Sciences Kyoto Prefectural University Kyoto 606\u20108522 Japan"},{"name":"National Institute of Advanced Industrial Science 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