{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:02:12Z","timestamp":1791324132155,"version":"4.3.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) are endogenous small <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s repressing target gene expression post\u2010transcriptionally and are critically involved in various development processes and responses to environmental stresses. <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 is highly conserved in land plants and targets several transcripts encoding copper proteins. Although it has been well documented that expression level of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 is strongly influenced by a variety of environmental conditions including copper availability, the biological function of this mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> is still unknown. Here we show that constitutive expression of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 results in enhanced growth of seedling and adult plant while knocking down mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 level by <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> insertions or the artificial mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> technique causes impaired growth. Further, we found that constitutively activated mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 is able to complement the growth defects of the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> lines. Regarding the molecular mechanism governing miR408 expression, we found that the transcription factors <jats:italic><jats:styled-content style=\"fixed-case\">SQUAMOSA PROMOTER BINDING PROTEIN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LIKE<\/jats:styled-content>7<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">SPL<\/jats:styled-content>7<\/jats:italic>) binds to the <jats:styled-content style=\"fixed-case\">GTAC<\/jats:styled-content> motifs in the <jats:italic><jats:styled-content style=\"fixed-case\">MIR<\/jats:styled-content>408<\/jats:italic> promoter in response to copper deficiency. Interestingly, constitutive activation of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 in the <jats:italic>spl7<\/jats:italic> background could partially rescue the severe growth defects of the mutant. Together these results demonstrate that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 is a powerful modulator of vegetative growth. Our finding thus reveals a novel control mechanism for vegetative development based on calculated mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>408 expression in response to environmental cues.<\/jats:p>","DOI":"10.1111\/tpj.12107","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T16:52:42Z","timestamp":1357404762000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["<i><scp>SQUAMOSA<\/scp> promoter binding protein\u2010like7<\/i> regulated microRNA408 is required for vegetative development in <scp>A<\/scp>rabidopsis"],"prefix":"10.1111","volume":"74","author":[{"given":"Huiyong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biology University of Virginia Charlottesville VA 22904 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