{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:52:12Z","timestamp":1791341532561,"version":"4.3.1"},"reference-count":80,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pathogen infection in plants triggers large\u2010scale transcriptional changes, both locally and systemically. Emerging evidence suggests that the<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rabidopsis<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ediator complex plays a crucial role in these transcriptional changes. Mediator is highly conserved in eukaryotes, and its core comprises more than 20 subunits organized into three modules named head, middle and tail. The head and middle modules interact with general transcription factors and<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>polymerase\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, whereas the tail module associates with activators, and signals through the head and middle modules to the basal transcription machinery. In Arabidopsis, three tail module subunits,<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>14,<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>15 and<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>16, have been identified. Both<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>15 and<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>16 have been implicated in plant immunity, but the role of<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>14 has not been established. Here, we report the characterization of an Arabidopsis T\u2013<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>insertion mutant of the<jats:italic><jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>14<\/jats:italic>gene. Similarly to the<jats:italic>med15<\/jats:italic>and\/or<jats:italic>med16<\/jats:italic>mutations, the<jats:italic>med14<\/jats:italic>mutation significantly suppresses salicylic acid\u2010induced defense responses, alters transcriptional changes induced by the avirulent bacterial pathogen<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>seudomonas syringae<\/jats:italic>pv.<jats:italic>tomato<\/jats:italic>(<jats:italic>Pst<\/jats:italic>)<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>3000\/<jats:italic>avrRpt2<\/jats:italic>, and renders plants susceptible to both<jats:italic>Pst<\/jats:italic><jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>3000\/<jats:italic>avrRpt2<\/jats:italic>and<jats:italic>Pst<\/jats:italic><jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>3000. The<jats:italic>med14<\/jats:italic>mutation also completely compromises biological induction of systemic acquired resistance (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>), indicating that the tail module as a whole is essential for<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>. Interestingly, unlike the<jats:italic>med16<\/jats:italic>mutation, which differentially affects expression of several<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>positive and negative regulators,<jats:italic>med14<\/jats:italic>inhibits induction of a large group of defense genes, including both<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>positive and negative regulators, suggesting that individual subunits of the Mediator tail module employ distinct mechanisms to regulate plant immune responses.<\/jats:p>","DOI":"10.1111\/tpj.12216","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T17:46:50Z","timestamp":1366652810000},"page":"484-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The<scp>A<\/scp>rabidopsis<scp>M<\/scp>ediator complex subunits<scp>MED<\/scp>14\/<scp>SWP<\/scp>and<scp>MED<\/scp>16\/<scp>SFR<\/scp>6\/<scp>IEN<\/scp>1 differentially regulate defense gene expression in plant immune responses"],"prefix":"10.1111","volume":"75","author":[{"given":"Xudong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Science University of Florida PO Box 110700 Gainesville FL 32611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Buffalo Buffalo NY 14203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Biotechnology Research University of Florida PO Box 103622 Gainesville FL 32610 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Buffalo Buffalo NY 14203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science University of Florida PO Box 110700 Gainesville FL 32611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35024111"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086391"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.23182"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905103106"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf614"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.05.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.8.2842-2852.2002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1164302"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00075.Billington"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.312298"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00830-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn349"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.103028"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/3869945"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81858-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01636"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.202697"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.03.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.098277"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.10.4.557"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00343.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.07.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.01.013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2010.04345.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6602"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.108.062364"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198524847.001.0001","volume-title":"Analysis of Longitudinal Data","author":"Diggle P. 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