{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:27:48Z","timestamp":1791077268367,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Polyadenylation of pre\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s by poly(A) polymerase (<jats:styled-content style=\"fixed-case\">PAPS<\/jats:styled-content>) is a critical process in eukaryotic gene expression. As found in vertebrates, plant genomes encode several isoforms of canonical nuclear <jats:styled-content style=\"fixed-case\">PAPS<\/jats:styled-content> enzymes. In <jats:italic>Arabidopsis thaliana<\/jats:italic> these isoforms are functionally specialized, with <jats:italic>PAPS1<\/jats:italic> affecting both organ growth and immune response, at least in part by the preferential polyadenylation of subsets of pre\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s. Here, we demonstrate that the opposite effects of <jats:italic>PAPS1<\/jats:italic> on leaf and flower growth reflect the different identities of these organs, and identify a role for <jats:italic>PAPS1<\/jats:italic> in the elusive connection between organ identity and growth patterns. The overgrowth of <jats:italic>paps1<\/jats:italic> mutant petals is due to increased recruitment of founder cells into early organ primordia, and suggests that <jats:italic>PAPS1<\/jats:italic> activity plays unique roles in influencing organ growth. By contrast, the leaf phenotype of <jats:italic>paps1<\/jats:italic> mutants is dominated by a constitutive immune response that leads to increased resistance to the biotrophic oomycete <jats:italic>Hyaloperonospora arabidopsidis<\/jats:italic> and reflects activation of the salicylic acid\u2010independent signalling pathway downstream of ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)\/PHYTOALEXIN DEFICIENT4 (PAD4). These findings provide an insight into the developmental and physiological basis of the functional specialization amongst plant PAPS isoforms.<\/jats:p>","DOI":"10.1111\/tpj.12421","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T10:04:51Z","timestamp":1388397891000},"page":"688-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Arabidopsis poly(A) polymerase <scp>PAPS<\/scp>1 limits founder\u2010cell recruitment to organ primordia and suppresses the salicylic acid\u2010independent immune response downstream of <scp>EDS<\/scp>1\/<scp>PAD<\/scp>4"],"prefix":"10.1111","volume":"77","author":[{"given":"Gerda","family":"Trost","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Biochemie und Biologie Universit\u00e4t Potsdam Karl\u2010Liebknecht\u2010Str. 24\u201025 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son 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