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This memory confers upon a plant the ability to subsequently activate defenses more robustly when challenged by a pest. In plants that have retained the memory of a prior, localized, foliar infection by a pathogen, the pathogen\u2010free distal organs develop immunity against subsequent infections by a broad\u2010spectrum of pathogens. The long\u2010term immunity conferred by this mechanism, which is termed systemic acquired resistance (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>), is inheritable over a few generations. Signaling mediated by the phenolic metabolite salicylic acid (SA) is critical for the manifestation of <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>. Recent studies have described the involvement of additional small metabolites in <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> signaling, including methyl salicylate, the abietane diterpenoid dehydroabietinal, the lysine catabolite pipecolic acid, a glycerol\u20103\u2010phosphate\u2010dependent factor and the dicarboxylic acid azelaic acid. Many of these metabolites can be systemically transported through the plant and probably facilitate communication by the primary infected tissue with the distal tissues, which is essential for the activation of <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>. Some of these metabolites have been implicated in the <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2010associated rapid activation of defenses in response to subsequent exposure to the pathogen, a mechanism termed priming. Here, we summarize the role of these signaling metabolites in <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>, and the relationship between them and SA signaling in <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/tpj.12464","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T15:10:35Z","timestamp":1391785835000},"page":"645-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Signaling by small metabolites in systemic acquired resistance"],"prefix":"10.1111","volume":"79","author":[{"given":"Jyoti","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of North Texas Denton TX 76203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnesh","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 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