{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:59:26Z","timestamp":1789901966059,"version":"4.0.1"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31330062"],"award-info":[{"award-number":["31330062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Program on the Development of Basic Research in China","award":["2012CB114005"],"award-info":[{"award-number":["2012CB114005"]}]},{"name":"National Program of High Technology Development of China","award":["2012AA10A303"],"award-info":[{"award-number":["2012AA10A303"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Summary<\/jats:title>\n \n The extensively studied\n A<\/jats:styled-content>\n rabidopsis phytoalexin deficient 4 (\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n ) gene plays an important role in\n A<\/jats:styled-content>\n rabidopsis disease resistance; however, the function of its sequence ortholog in rice is unknown. Here, we show that rice\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n appears not to be the functional ortholog of\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n in host\u2010pathogen interactions, and that the Os\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n encodes a plasma membrane protein but that\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n encodes a cytoplasmic and nuclear protein. Suppression of Os\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n by\n RNA<\/jats:styled-content>\n interference (\n RNA<\/jats:styled-content>\n i) increased rice susceptibility to the biotrophic pathogen\n \n X<\/jats:styled-content>\n anthomonas oryzae\n <\/jats:italic>\n pv.\n oryzae<\/jats:italic>\n (\n \n X<\/jats:styled-content>\n oo\n <\/jats:italic>\n ), which causes bacteria blight disease in local tissue.\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n \u2010\n RNA<\/jats:styled-content>\n i plants also show compromised wound\u2010induced systemic resistance to\n \n X<\/jats:styled-content>\n oo\n <\/jats:italic>\n . The increased susceptibility to\n \n X<\/jats:styled-content>\n oo\n <\/jats:italic>\n was associated with reduced accumulation of jasmonic acid (\n JA<\/jats:styled-content>\n ) and phytoalexin momilactone\n A<\/jats:styled-content>\n (\n MOA<\/jats:styled-content>\n ). Exogenous application of\n JA<\/jats:styled-content>\n complemented the phenotype of\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n \u2010\n RNA<\/jats:styled-content>\n i plants in response to\n \n X<\/jats:styled-content>\n oo\n <\/jats:italic>\n . The following results suggest that\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n functions differently than\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n in response to pathogen infection. First,\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n plays an important role in wound\u2010induced systemic resistance, whereas\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n mediates systemic acquired resistance. Second,\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n \u2010involved defense signaling against\n \n X<\/jats:styled-content>\n oo\n <\/jats:italic>\n is\n JA<\/jats:styled-content>\n \u2010dependent, but\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n \u2010involved defense signaling against biotrophic pathogens is salicylic acid\u2010dependent. Finally,\n O<\/jats:styled-content>\n s\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n is required for the accumulation of terpenoid\u2010type phytoalexin\n MOA<\/jats:styled-content>\n in rice\u2010bacterium interactions, but\n A<\/jats:styled-content>\n t\n \n PAD<\/jats:styled-content>\n 4\n <\/jats:italic>\n \u2010mediated resistance is associated with the accumulation of indole\u2010type phytoalexin camalexin.\n <\/jats:p>","DOI":"10.1111\/tpj.12500","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T11:04:36Z","timestamp":1394535876000},"page":"619-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Rice\n O<\/scp>\n s\n \n PAD<\/scp>\n 4\n <\/i>\n functions differently from\n A<\/scp>\n rabidopsis\n A<\/scp>\n t\n \n PAD<\/scp>\n 4\n <\/i>\n in host\u2010pathogen interactions"],"prefix":"10.1111","volume":"78","author":[{"given":"Yinggen","family":"Ke","sequence":"first","affiliation":[{"name":"National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 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