{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:00:26Z","timestamp":1774929626605,"version":"3.50.1"},"reference-count":87,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Poaceae plants release 2\u2032\u2010deoxymugineic acid (<jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content>) and related phytosiderophores to chelate iron (Fe), which often exists as insoluble Fe(III) in the rhizosphere, especially under high pH conditions. Although the molecular mechanisms behind the biosynthesis and secretion of <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> have been studied extensively, little information is known about whether <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> has biological roles other than chelating Fe <jats:italic>in vivo<\/jats:italic>. Here, we demonstrate that hydroponic cultures of rice (<jats:italic>Oryza sativa<\/jats:italic>) seedlings show almost complete restoration in shoot height and soil\u2010plant analysis development (<jats:styled-content style=\"fixed-case\">SPAD<\/jats:styled-content>) values after treatment with 3\u201330\u00a0\u03bc<jats:sc>m <\/jats:sc><jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> at high pH (pH 8.0), compared with untreated control seedlings at normal pH (pH 5.8). These changes were accompanied by selective accumulation of Fe over other metals. While this enhanced growth was evident under high pH conditions, <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> application also enhanced seedling growth under normal pH conditions in which Fe was fairly accessible. Microarray and q<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analyses revealed that exogenous <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> application attenuated the increased expression levels of various genes related to Fe transport and accumulation. Surprisingly, despite the preferential utilization of ammonium over nitrate as a nitrogen source by rice, <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> application also increased nitrate reductase activity and the expression of genes encoding high\u2010affinity nitrate transporters and nitrate reductases, all of which were otherwise considerably lower under high pH conditions. These data suggest that exogenous <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content> not only plays an important role in facilitating the uptake of environmental Fe, but also orchestrates Fe and nitrate assimilation for optimal growth under high pH conditions.<\/jats:p>","DOI":"10.1111\/tpj.12722","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T15:35:21Z","timestamp":1415806521000},"page":"233-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["2\u2032\u2010Deoxymugineic acid promotes growth of rice (<i>Oryza sativa<\/i> L.) by orchestrating iron and nitrate uptake processes under high pH conditions"],"prefix":"10.1111","volume":"81","author":[{"given":"Ryoichi","family":"Araki","sequence":"first","affiliation":[{"name":"Division of Integrative Biomolecular Function Bioorganic Research Institute Suntory Foundation for Life Sciences 1\u20101\u20101 Wakayamadai Shimamoto Mishima Osaka 618\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Kousaka","sequence":"additional","affiliation":[{"name":"Division of Integrative Biomolecular Function Bioorganic Research Institute Suntory Foundation for Life Sciences 1\u20101\u20101 Wakayamadai Shimamoto Mishima Osaka 618\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Hokkaido University Kita\u2010ku Sapporo 060\u20100810 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Integrative Biomolecular Function Bioorganic Research Institute Suntory Foundation for Life Sciences 1\u20101\u20101 Wakayamadai Shimamoto Mishima Osaka 618\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Integrative Biomolecular Function Bioorganic Research Institute Suntory Foundation for Life Sciences 1\u20101\u20101 Wakayamadai Shimamoto Mishima Osaka 618\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-009-9500-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1270\/jsbbs.56.295"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcr126"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604133200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7909.2008.00642.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.50.1.277"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.50.2.208"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.18.6825"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-4389-9_5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.001263"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/ssr015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erj050"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.54.031902.135018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053080"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcn207"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erq403"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00140-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2009.04.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12173"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(80)69026-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac197334030553"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1996.tb00202.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.119.2.471"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pcp.a029120"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2003.01878.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806042200"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02624.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610555104"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/01904168809363829"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00380768.2001.10408390"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042811-105522"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.86.900"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3792"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026438615520"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.119.3.1041"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2009.12.003"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2011.04506.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.135418"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1999.00480.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17732"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1996.tb00522.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(93)85323-J"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erm066"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00352a024"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(99)80043-0"},{"key":"e_1_2_6_47_1","first-page":"1081","article-title":"Methionine as a dominant precursor of phytosiderophores in graminaceae plants","volume":"28","author":"Mori S.","year":"1987","journal-title":"Plant Cell Physiol."},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2002.01312.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.3.612"},{"key":"e_1_2_6_50_1","first-page":"401","article-title":"Expression of a gene specific for iron deficiency (Ids3) in the roots of Hordeum vulgare","volume":"34","author":"Nakanishi H.","year":"1993","journal-title":"Plant Cell Physiol."},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200702403"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00298a004"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/00380768.2004.10408585"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.180026"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/ssq049"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2007.03149.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcg036"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00029608"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-297"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.005280"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.166"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.04.019"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.71.4.949"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.80.1.175"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050196"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3040.2000.00634.x"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/00380768.1988.10416473"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.93.4.1497"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0765.2007.00205.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi050981y"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/00380768.1981.10431289"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/01904168409363213"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.121.3.947"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/88143"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0531-5"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02220801"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/00380768.2004.10408588"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.001388"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2008.06.013"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.8.1491"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.021253"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.044610"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2007.01761.x"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042811-105532"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.100.3.1427"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2011.02335.x"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.128132"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.123737"}],"container-title":["The Plant Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftpj.12722","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tpj.12722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tpj.12722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tpj.12722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:29:11Z","timestamp":1696202951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tpj.12722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/tpj.12722"],"URL":"https:\/\/doi.org\/10.1111\/tpj.12722","archive":["Portico"],"relation":{},"ISSN":["0960-7412","1365-313X"],"issn-type":[{"value":"0960-7412","type":"print"},{"value":"1365-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]},"assertion":[{"value":"2014-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}