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It has been shown that\n SA<\/jats:styled-content>\n prevents\n NPR<\/jats:styled-content>\n 1 turnover under non\u2010inducing and\n LAR<\/jats:styled-content>\n \/\n SAR<\/jats:styled-content>\n \u2010inducing conditions, but how cellular\n NPR<\/jats:styled-content>\n 1 homeostasis is maintained remains unclear. Here, we show that the phytohormone abscisic acid (\n ABA<\/jats:styled-content>\n ) and\n SA<\/jats:styled-content>\n antagonistically influence cellular\n NPR<\/jats:styled-content>\n 1 protein levels.\n ABA<\/jats:styled-content>\n promotes\n NPR<\/jats:styled-content>\n 1 degradation via the\n CUL<\/jats:styled-content>\n 3\n \n NPR<\/jats:sup>\n <\/jats:styled-content>\n 3\/<\/jats:sup>\n \n NPR<\/jats:sup>\n <\/jats:styled-content>\n 4<\/jats:sup>\n complex\u2010mediated proteasome pathway, whereas\n SA<\/jats:styled-content>\n may protect\n NPR<\/jats:styled-content>\n 1 from\n ABA<\/jats:styled-content>\n \u2010promoted degradation through phosphorylation. Furthermore, we demonstrate that the timing and strength of\n SA<\/jats:styled-content>\n and\n ABA<\/jats:styled-content>\n signaling are critical in modulating\n NPR<\/jats:styled-content>\n 1 accumulation and target gene expression. Perturbing\n ABA<\/jats:styled-content>\n or\n SA<\/jats:styled-content>\n signaling in adjacent tissues alters the temporal dynamic pattern of\n NPR<\/jats:styled-content>\n 1 accumulation and target gene transcription. Finally, we show that sequential\n SA<\/jats:styled-content>\n and\n ABA<\/jats:styled-content>\n treatment leads to dynamic changes in\n NPR<\/jats:styled-content>\n 1 protein levels and target gene expression. Our results revealed a tight correlation between sequential\n SA<\/jats:styled-content>\n and\n ABA<\/jats:styled-content>\n signaling and dynamic changes in\n NPR<\/jats:styled-content>\n 1 protein levels and\n NPR<\/jats:styled-content>\n 1\u2010dependent transcription in plant immune responses.\n <\/jats:p>","DOI":"10.1111\/tpj.13141","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T23:26:59Z","timestamp":1455146819000},"page":"20-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Abscisic acid promotes proteasome\u2010mediated degradation of the transcription coactivator\n NPR<\/scp>\n 1 in\n Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"86","author":[{"given":"Yezhang","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Science University of Florida PO Box\u00a0110700 Gainesville FL\u00a032611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dommel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science University of Florida PO Box\u00a0110700 Gainesville FL\u00a032611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Science University of Florida PO Box\u00a0110700 Gainesville FL\u00a032611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.13.3797"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031130"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.099226"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-21-6-0709"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81858-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10265-011-0409-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.10.4.557"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.11.2175"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-13-102"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6602"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00763"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.137943"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11162"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/143.2.973"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.098574"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2013.00252"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2008.00346.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-23-6-0791"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1970"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.04.045"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.12.2339"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401925"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1996.10040655.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.096198"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00777"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.054"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1071\/FP02231"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.152603"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00429-X"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5298.400"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.046953"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.9.3.425"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.200154"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1633615100"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.038"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156970"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1890\/02-0710"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2009.03.006"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.03875.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601575"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.615"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.050908.135202"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2290"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-738-9_2"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/35107108"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.039"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.05.008"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109275200"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067413"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.054296"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1105\/TPC.010115"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.157016"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02903.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.103317"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.046367"}],"container-title":[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