{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:51:11Z","timestamp":1790502671700,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T00:00:00Z","timestamp":1486771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP1095157"],"award-info":[{"award-number":["DP1095157"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003195","name":"Ministerie van Economische Zaken","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>We have identified the tomato I<\/jats:italic> gene for resistance to the Fusarium wilt fungus Fusarium oxysporum<\/jats:italic> f. sp. lycopersici<\/jats:italic> (Fol<\/jats:italic>) and show that it encodes a membrane\u2010anchored leucine\u2010rich repeat receptor\u2010like protein (LRR<\/jats:styled-content>\u2010RLP<\/jats:styled-content>). Unlike most other LRR<\/jats:styled-content>\u2010RLP<\/jats:styled-content> genes involved in plant defence, the I<\/jats:italic> gene is not a member of a gene cluster and contains introns in its coding sequence. The I<\/jats:italic> gene encodes a loopout domain larger than those in most other LRR<\/jats:styled-content>\u2010RLP<\/jats:styled-content>s, with a distinct composition rich in serine and threonine residues. The I protein also lacks a basic cytosolic domain. Instead, this domain is rich in aromatic residues that could form a second transmembrane domain. The I protein recognises the Fol<\/jats:italic> Avr1 effector protein, but, unlike many other LRR<\/jats:styled-content>\u2010RLP<\/jats:styled-content>s, recognition specificity is determined in the C\u2010terminal half of the protein by polymorphic amino acid residues in the LRR<\/jats:styled-content>s just preceding the loopout domain and in the loopout domain itself. Despite these differences, we show that I\/Avr1\u2010dependent necrosis in Nicotiana benthamiana<\/jats:italic> depends on the LRR<\/jats:styled-content> receptor\u2010like kinases (RLK<\/jats:styled-content>s) SERK<\/jats:styled-content>3\/BAK<\/jats:styled-content>1 and SOBIR<\/jats:styled-content>1. Sequence comparisons revealed that the I protein and other LRR<\/jats:styled-content>\u2010RLP<\/jats:styled-content>s involved in plant defence all carry residues in their last LRR<\/jats:styled-content> and C\u2010terminal LRR<\/jats:styled-content> capping domain that are conserved with SERK<\/jats:styled-content>3\/BAK<\/jats:styled-content>1\u2010interacting residues in the same relative positions in the LRR<\/jats:styled-content>\u2010RLK<\/jats:styled-content>s BRI<\/jats:styled-content>1 and PSKR<\/jats:styled-content>1. Tyrosine mutations of two of these conserved residues, Q922 and T925, abolished I\/Avr1\u2010dependent necrosis in N. benthamiana<\/jats:italic>, consistent with similar mutations in BRI<\/jats:styled-content>1 and PSKR<\/jats:styled-content>1 preventing their interaction with SERK<\/jats:styled-content>3\/BAK<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/tpj.13458","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T07:22:57Z","timestamp":1482218577000},"page":"1195-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["The tomato I<\/i> gene for Fusarium wilt resistance encodes an atypical leucine\u2010rich repeat receptor\u2010like protein whose function is nevertheless dependent on SOBIR<\/scp>1 and SERK<\/scp>3\/BAK<\/scp>1"],"prefix":"10.1111","volume":"89","author":[{"given":"Ann\u2010Maree","family":"Catanzariti","sequence":"first","affiliation":[{"name":"Division of Plant Sciences Research School of Biology The Australian National University Acton ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong T. T.","family":"Do","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences Research School of Biology The Australian National University Acton ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bru","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences Research School of Biology The Australian National University Acton ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"de Sain","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise F.","family":"Thatcher","sequence":"additional","affiliation":[{"name":"CSIRO Agriculture and Food Centre for Environment and Life Sciences Wembley WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Rep","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-5822","authenticated-orcid":false,"given":"David A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences Research School of Biology The Australian National University Acton ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10306"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nplants.2015.140"},{"key":"e_1_2_6_4_1","first-page":"303","article-title":"Physiological specialization in the Tomato wilt fungus Fusarium oxysporum f. sp. lycopersici","volume":"70","author":"Alexander L.J.","year":"1945","journal-title":"J. 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