{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:56Z","timestamp":1792793876161,"version":"4.5.0"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ZE467\/6\u20101"],"award-info":[{"award-number":["ZE467\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Members of the <jats:italic><jats:styled-content style=\"fixed-case\">MILDEW RESISTANCE LOCUS<\/jats:styled-content>\u00a0O<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>)<\/jats:italic> gene family confer susceptibility to powdery mildews in different plant species, and their existence therefore seems to be disadvantageous for the plant. We recognized that expression of the Arabidopsis <jats:italic><jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>2<\/jats:italic> gene is induced after inoculation with the bacterial pathogen <jats:italic>Pseudomonas syringae<\/jats:italic>, promoted by salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) signaling, and systemically enhanced in the foliage of plants exhibiting systemic acquired resistance (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>). Importantly, distinct <jats:italic>mlo2<\/jats:italic> mutant lines were unable to systemically increase resistance to bacterial infection after inoculation with <jats:italic>P.\u00a0syringae<\/jats:italic>, indicating that the function of <jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>2 is necessary for biologically induced <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> in Arabidopsis. Our data also suggest that the close homolog <jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>6 has a supportive but less critical role in <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>. In contrast to <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>, basal resistance to bacterial infection was not affected in <jats:italic>mlo2<\/jats:italic>. Remarkably, <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2010defective <jats:italic>mlo2<\/jats:italic> mutants were still competent in systemically increasing the levels of the <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2010activating metabolites pipecolic acid (Pip) and <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> after inoculation, and to enhance <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2010related gene expression in distal plant parts. Furthermore, although <jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>2 was not required for <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\u2010 or Pip\u2010inducible defense gene expression, it was essential for the proper induction of disease resistance by both <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> signals. We conclude that <jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>2 acts as a critical downstream component in the execution of <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> to bacterial infection, being required for the translation of elevated defense responses into disease resistance. Moreover, our data suggest a function for <jats:styled-content style=\"fixed-case\">MLO<\/jats:styled-content>2 in the activation of plant defense priming during challenge by <jats:italic>P.\u00a0syringae<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/tpj.13920","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T16:16:04Z","timestamp":1523895364000},"page":"1064-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A critical role for Arabidopsis <scp>MILDEW RESISTANCE LOCUS<\/scp> O2 in systemic acquired resistance"],"prefix":"10.1111","volume":"94","author":[{"given":"Katrin","family":"Gruner","sequence":"first","affiliation":[{"name":"Institute for Molecular Ecophysiology of Plants Department of Biology Heinrich Heine University Universit\u00e4tsstra\u00dfe 1 D\u00fcsseldorf D\u201040225 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