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Cold stress response in Arabidopsis root is directly linked to inhibition of the endosomal trafficking of auxin efflux carriers. However, the cellular components that link cold stress and the endosomal trafficking remain elusive. By screening available endosomal trafficking mutants against root growth recovery response under cold stress, we identified <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content>, a <jats:styled-content style=\"fixed-case\">SEC<\/jats:styled-content>7 containing <jats:styled-content style=\"fixed-case\">ARF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GEF<\/jats:styled-content>, as a major modulator of cold response. Contrasting response of partial loss of function mutant <jats:italic>gnom<\/jats:italic><jats:sup><jats:italic>B4049\/emb30\u20101<\/jats:italic><\/jats:sup> and the engineered Brefeldin A (<jats:styled-content style=\"fixed-case\">BFA<\/jats:styled-content>)\u2010resistant <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content> line, both of which contain mutations within <jats:styled-content style=\"fixed-case\">SEC<\/jats:styled-content>7 domain, to cold stress at the whole\u2010plant level highlights the importance of this domain in modulating the cold response pathway of plants. Cold stress selectively and transiently inhibits <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content> expression. The engineered point mutation at 696 amino acid position (Methionine to Leucine) that makes <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content> resistant to <jats:styled-content style=\"fixed-case\">BFA<\/jats:styled-content> in fact results in overexpression of <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content> both at transcriptional and translational levels, and also alters its subcellular localization. Overexpression and altered cellular localization of <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content> were found to be directly linked to conferring striking cold\u2010resistant phenotype in Arabidopsis. Collectively, these results provide a mechanistic link between <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BFA<\/jats:styled-content>\u2010sensitive <jats:styled-content style=\"fixed-case\">GNOM<\/jats:styled-content>\u2010regulated trafficking and cold stress.<\/jats:p>","DOI":"10.1111\/tpj.14137","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T11:28:40Z","timestamp":1540553320000},"page":"500-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Cold stress response in <i>Arabidopsis thaliana<\/i> is mediated by <scp>GNOM ARF<\/scp>\u2010<scp>GEF<\/scp>"],"prefix":"10.1111","volume":"97","author":[{"given":"Mohammad A.","family":"Ashraf","sequence":"first","affiliation":[{"name":"United Graduate School of Agricultural Sciences Iwate University Morioka 020\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-899X","authenticated-orcid":false,"given":"Abidur","family":"Rahman","sequence":"additional","affiliation":[{"name":"United Graduate School of Agricultural Sciences Iwate University Morioka 020\u20108550 Japan"},{"name":"Department of Plant Bio Sciences Faculty of Agriculture Iwate University Morioka 020\u20108550 Japan"},{"name":"Agro\u2010Innovation Center Iwate University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erj129"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8227-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.056515"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.113.2.493"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.3.861"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10791"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172979"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00634.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00896"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02076"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1999.00620.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-011-0473-9","volume-title":"The Plant Hormone Concept: Concentration, Sensitivity and Transport","author":"Davies P.J.","year":"1995"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.057711"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2270"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.2007.00920.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.127779"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011509"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110682108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00003-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00926"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123209"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.107.053876"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.7197"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010026"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.113.115881"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2011.06.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.106.084533"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05046"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/152.4.1543"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.06.006"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.01.046"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(88)91109-7"},{"key":"e_1_2_8_36_1","first-page":"97","article-title":"Characteristics of cold\u2010sensitive cell division mutant of Escherichia coli K\u201012","volume":"41","author":"Kudo T.","year":"1977","journal-title":"Agric. 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