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Here mutations in the KAI2 (KARRIKIN INSENSITIVE) \u03b1\/\u03b2\u2010fold hydrolase and the MAX2 (MORE AXILLARY GROWTH 2) F\u2010box leucine\u2010rich protein, which together perceive karrikins (smoke\u2010derived butenolides), caused alteration in root skewing in <jats:italic>Arabidopsis thaliana<\/jats:italic>. This phenotype was independent of endogenous strigolactones perception by the D14 \u03b1\/\u03b2\u2010fold hydrolase and MAX2. Thus, KAI2\/MAX2 effect on root growth may be through the perception of endogenous KAI2\u2010ligands (KLs), which have yet to be identified. Upon perception of a ligand, a KAI2\/MAX2 complex is formed together with additional target proteins before ubiquitination and degradation through the 26S proteasome. Using a genetic approach, we show that SMAX1 (SUPPRESSOR OF MAX2\u20101)\/SMXL2 and SMXL6,7,8 (SUPPRESSOR OF MAX2\u20101\u2010LIKE) are also likely degradation targets for the KAI2\/MAX2 complex in the context of root skewing. In <jats:italic>A. thaliana<\/jats:italic> therefore, KAI2 and MAX2 act to limit root skewing, while <jats:italic>kai2<\/jats:italic>'s gravitropic and mechano\u2010sensing responses remained largely unaffected. Many proteins are involved in root skewing, and we investigated the link between MAX2 and two members of the SKS\/SKU family. Though KLs are yet to be identified in plants, our data support the hypothesis that they are present and can affect root skewing.<\/jats:p>","DOI":"10.1111\/tpj.14233","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T20:14:45Z","timestamp":1547928885000},"page":"607-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Impairment in karrikin but not strigolactone sensing enhances root skewing in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"98","author":[{"given":"St\u00e9phanie M.","family":"Swarbreck","sequence":"first","affiliation":[{"name":"Department of Plant Sciences University of Cambridge Cambridge CB2 3EA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Guerringue","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences University of Cambridge Cambridge CB2 3EA UK"},{"name":"ENS de Lyon \u2010 Site Monod Lyon 69007 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Matthus","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences University of Cambridge Cambridge CB2 3EA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona J. 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