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Among them, <jats:styled-content style=\"fixed-case\">CAMTA<\/jats:styled-content>3 in Arabidopsis has been intensively studied and shown to function redundantly with <jats:styled-content style=\"fixed-case\">CAMTA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CAMTA<\/jats:styled-content>2 to negatively regulate plant immunity. The <jats:italic>camta1\/2\/3<\/jats:italic> triple mutant accordingly exhibits severe dwarfism due to autoimmunity. Here, through a suppressor screen using <jats:italic>camta1\/2\/3<\/jats:italic> triple mutant, we found that a mutation in <jats:italic>Cyclin\u2010Dependent Kinase 8<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>8<\/jats:italic>) partially suppresses the dwarfism and constitutive resistance phenotypes of <jats:italic>camta1\/2\/3<\/jats:italic>. <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>8 positively regulates steady\u2010state salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) levels and systemic required resistance (<jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>). The expression of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> biosynthesis genes such as <jats:italic><jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">EDS<\/jats:styled-content>5<\/jats:italic> is down\u2010regulated in <jats:italic>cdk8<\/jats:italic> mutants under uninfected conditions, suggesting that <jats:styled-content style=\"fixed-case\">CDK<\/jats:styled-content>8 contributes to the transcriptional regulation of these <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> pathway genes. Knocking out another Mediator kinase module member <jats:italic><jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>12<\/jats:italic> yielded similar defects including decreased steady\u2010state <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> level and compromised <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>, suggesting that the whole Mediator kinase module contributes to the transcriptional regulation of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/tpj.14278","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T04:59:32Z","timestamp":1549774772000},"page":"842-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Mediator kinase module serves as a positive regulator of salicylic acid accumulation and systemic acquired resistance"],"prefix":"10.1111","volume":"98","author":[{"given":"Jianhua","family":"Huang","sequence":"first","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia Vancouver BC Canada V6T 1Z4"},{"name":"Department of Botany University of British Columbia Vancouver BC Canada V6T 1Z4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver BC Canada V6T 1Z4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto R.","family":"Orduna","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of British Columbia Vancouver BC Canada V6T 1Z1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Jetter","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver BC Canada 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