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However, similar to other epigenetic regulators, there is accumulating evidence for their role in the regulation of stress and immune\u2010related pathways. In the current study we show that the <jats:styled-content style=\"fixed-case\">PRC<\/jats:styled-content>1 protein <jats:styled-content style=\"fixed-case\">LHP<\/jats:styled-content>1 is required for the repression of the <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>2 branch of jasmonic acid (<jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>)\/ethylene (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) pathway of immunity. Loss of <jats:italic><jats:styled-content style=\"fixed-case\">LHP<\/jats:styled-content>1<\/jats:italic> induces the reduction in H3K27me3 levels in the gene bodies of <jats:italic><jats:styled-content style=\"fixed-case\">ANAC<\/jats:styled-content>019<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ANAC<\/jats:styled-content>055,<\/jats:italic> as well as some of their targets, leading to their transcriptional upregulation. Consistently, increased expression of these two transcription factors leads to the misregulation of several of their genomic targets. The <jats:italic>lhp1<\/jats:italic> mutant mimics the <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">ANAC<\/jats:styled-content>019<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">ANAC<\/jats:styled-content>055<\/jats:italic> overexpressers in several of their phenotypes, including increased aphid resistance, <jats:styled-content style=\"fixed-case\">abscisic acid (ABA)<\/jats:styled-content> sensitivity and drought tolerance. In addition, like the <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ANAC<\/jats:styled-content><\/jats:italic> overexpressers, <jats:italic>lhp1<\/jats:italic> displays reduced salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) content caused by a deregulation of <jats:italic><jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BSMT<\/jats:styled-content>1<\/jats:italic>, as well as increased susceptibility to the hemibiotrophic pathogen <jats:italic>Pseudomonas syringae<\/jats:italic> pv. tomato <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>3000. Together, our results indicate that <jats:styled-content style=\"fixed-case\">LHP<\/jats:styled-content>1 regulates the expression of stress\u2010responsive genes as well as the homeostasis and responses to the stress hormones <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>. This protein emerges as a key chromatin player fine tuning the complex balance between developmental and stress\u2010responsive processes.<\/jats:p>","DOI":"10.1111\/tpj.14502","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T20:24:28Z","timestamp":1566505468000},"page":"1118-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["The Polycomb protein <scp>LHP<\/scp>1 regulates <i>Arabidopsis thaliana<\/i> stress responses through the repression of the <scp>MYC<\/scp>2\u2010dependent branch of immunity"],"prefix":"10.1111","volume":"100","author":[{"given":"Juan Sebastian","family":"Ramirez\u2010Prado","sequence":"first","affiliation":[{"name":"Institute of Plant Sciences Paris\u2010Saclay (IPS2) CNRS INRA University Paris\u2010Sud University of Evry University Paris\u2010Diderot Sorbonne Paris\u2010Cite University of Paris\u2010Saclay Batiment 630 91405 Orsay 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