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Accession no.\u00a01 of <jats:italic>Aegilops variabilis<\/jats:italic>, a relative of <jats:italic>Triticum aestivum<\/jats:italic> (bread wheat), is highly resistant to CCN. Our previous study demonstrated that the expression of the phenylalanine ammonia lyase (PAL) gene <jats:italic>AevPAL1<\/jats:italic> in <jats:italic>Ae.\u00a0variabilis<\/jats:italic> is strongly induced by CCN. PAL, the first enzyme of phenylpropanoid metabolism, is involved in abiotic and biotic stress responses. However, its role in plant\u2013CCN interaction remains unknown. In the present study, we proved that <jats:italic>AevPAL1<\/jats:italic> helps to confer CCN resistance through affecting the synthesis of salicylic acid (SA) and downstream secondary metabolites. The silencing of <jats:italic>AevPAL1<\/jats:italic> increased the incidence of CCN infection in roots and decreased the accumulation of SA and phenylalanine (Phe)\u2010derived specialized metabolites. The exogenous pre\u2010application of SA also improved CCN resistance. Additionally, the functions of PAL in phenylpropanoid metabolism correlated with tryptophan decarboxylase (TDC) functioning in tryptophan metabolism pathways. The silencing of either <jats:italic>AevPAL1<\/jats:italic> or <jats:italic>AevTDC1<\/jats:italic> exhibited a concomitant reduction in the expression of both genes and the contents of metabolites downstream of PAL and TDC. These results suggested that <jats:italic>AevPAL1<\/jats:italic>, possibly in coordination with <jats:italic>AevTDC1<\/jats:italic>, positively contributes to CCN resistance by altering the downstream secondary metabolites and SA content in <jats:italic>Ae.\u00a0variabilis<\/jats:italic>. Moreover, <jats:italic>AevPAL1<\/jats:italic> overexpression significantly enhanced CCN resistance in bread wheat and did not exhibit significant negative effects on yield\u2010related traits, suggesting that <jats:italic>AevPAL1<\/jats:italic> is valuable for the genetic improvement of CCN resistance in bread wheat.<\/jats:p>","DOI":"10.1111\/tpj.15316","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T18:29:12Z","timestamp":1620757752000},"page":"698-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["PAL\u2010mediated SA biosynthesis pathway contributes to nematode resistance in wheat"],"prefix":"10.1111","volume":"107","author":[{"given":"Haili","family":"Zhang","sequence":"first","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 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