{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:01:12Z","timestamp":1787983272753,"version":"build-2784847793"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672115"],"award-info":[{"award-number":["31672115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2452019016"],"award-info":[{"award-number":["2452019016"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Glyoxalase I (GLYI) is part of the glyoxalase system; its major function is the detoxification of \u03b1\u2010ketoaldehydes, including the potent and cytotoxic methylglyoxal (MG). Methylglyoxal disrupts mitochondrial respiration and increases production of reactive oxygen species (ROS), which also increase during pathogen infection of plant tissues; however, there have been few studies relating the glyoxalase system to the plant pathogen response. We used the promoter of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    to screen the upstream transcription factors and report a NAC (NAM\/ATAF\/CUC) domain\u2010containing transcription factor\n                    <jats:italic>VvNAC72<\/jats:italic>\n                    in grapevine, which is localized to the nucleus. Our results show that\n                    <jats:italic>VvNAC72<\/jats:italic>\n                    expression is induced by downy mildew,\n                    <jats:italic>Plasmopara viticola<\/jats:italic>\n                    , while the transcript level of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    decreases. Further analysis revealed that VvNAC72 can bind directly to the promoter region of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    via the CACGTG element, leading to inhibition of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    transcription. Stable overexpression of\n                    <jats:italic>VvNAC72<\/jats:italic>\n                    in grapevine and tobacco showed a decreased expression level of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    and increased content of MG and ROS, as well as stronger resistance to pathogen stress. Taken together, these results demonstrate that grapevine\n                    <jats:italic>VvNAC72<\/jats:italic>\n                    negatively modulates detoxification of MG through repression of\n                    <jats:italic>VvGLYI\u20104<\/jats:italic>\n                    , and finally enhances resistance to downy mildew, at least in part, via the modulation of MG\u2010associated ROS homeostasis through a salicylic acid\u2010mediated defense pathway.\n                  <\/jats:p>","DOI":"10.1111\/tpj.15447","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T04:22:57Z","timestamp":1627446177000},"page":"394-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Glyoxalase I\u20104 functions downstream of NAC72 to modulate downy mildew resistance in grapevine"],"prefix":"10.1111","volume":"108","author":[{"given":"Tiemei","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas College of Horticulture Northwest A&amp;F University Yangling Shaanxi 712100 China"},{"name":"Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of Agriculture Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas College of Horticulture Northwest A&amp;F University Yangling Shaanxi 712100 China"},{"name":"Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of Agriculture Yangling Shaanxi 712100 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