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A homozygous Arabidopsis\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    null mutant is viable, but exhibits diverse phenotypic alterations, including delayed root development, late flowering, shorter siliques with fewer seeds, narrower leaves and petals, and unusual numbers of floral organs. Here, we report that the\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    mutant presents an unexpected constitutive iron deficiency phenotype characterized by altered metal distribution in the plant. RNA\u2010Sequencing highlighted severe perturbations in metal homeostasis, the phenylpropanoid pathway, oxidative stress responses, and reproductive development. Ionomic quantification and histochemical staining revealed strong iron accumulation in the\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    root tissues accompanied by iron starvation in aerial parts. Mis\u2010splicing of several key iron homeostasis genes, including\n                    <jats:italic>BTS<\/jats:italic>\n                    ,\n                    <jats:italic>bHLH104<\/jats:italic>\n                    ,\n                    <jats:italic>PYE<\/jats:italic>\n                    ,\n                    <jats:italic>FRD3<\/jats:italic>\n                    , and\n                    <jats:italic>ZIF1<\/jats:italic>\n                    , was observed in\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    roots. We showed that some\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    developmental abnormalities can be complemented by exogenous iron supply. Our findings provide new insight into the molecular mechanisms governing the phenotypes of the\n                    <jats:italic>sr45\u20101<\/jats:italic>\n                    mutant.\n                  <\/jats:p>","DOI":"10.1111\/tpj.15740","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T10:43:30Z","timestamp":1647686610000},"page":"1332-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Altered metal distribution in the\n                    <i>sr45\u20101<\/i>\n                    Arabidopsis mutant causes developmental defects"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-2404","authenticated-orcid":false,"given":"Steven","family":"Fanara","sequence":"first","affiliation":[{"name":"InBioS\u2010PhytoSystems, Functional Genomics and Plant Molecular Imaging and Centre for Assistance in Technology of Microscopy (CAREm) 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