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The objective of this research is to identify novel genes that participated in the regulation of Fe\u2010deficiency stress in <jats:italic>Arabidopsis thaliana<\/jats:italic>. A basic helix\u2013loop\u2013helix (bHLH) transcription factor (MYC1) was identified to be interacting with the FER\u2010LIKE IRON DEFICIENCY\u2010INDUCED TRANSCRIPTION FACTOR (FIT) using a yeast\u2010two\u2010hybrid assay. Transcript\u2010level analysis showed that there was a decrease in MYC1 expression in Arabidopsis to cope with Fe\u2010deficiency stress. Functional deficiency of <jats:italic>MYC1<\/jats:italic> in Arabidopsis leads to an increase in Fe\u2010deficiency tolerance and Fe\u2010accumulation, whereas <jats:italic>MYC1<\/jats:italic>\u2010overexpressing plants have an enhanced sensitivity to Fe\u2010deficiency stress. Additionally, <jats:italic>MYC1<\/jats:italic> inhibited the formation of FIT and bHLH38\/39 heterodimers, which suppressed the expressed level for Fe acquisition genes <jats:italic>FRO2<\/jats:italic> and <jats:italic>IRT1<\/jats:italic> during Fe\u2010deficiency stress. These results showed that <jats:italic>MYC1<\/jats:italic> functions as a negative modulator of the Fe\u2010deficiency stress response by inhibiting the formation of FIT and bHLH38\/39 heterodimers, thereby suppressing the binding of FIT and bHLH38\/39 heterodimers to the promoters of <jats:italic>FRO2<\/jats:italic> and <jats:italic>IRT1<\/jats:italic> to modulate Fe intake during Fe\u2010deficiency stress. Overall, the findings of this study elucidated the role of MYC1 in coping with Fe\u2010deficiency stress, and provided potential targets for the developing of crop varieties resistant to Fe\u2010deficiency stress.<\/jats:p>","DOI":"10.1111\/tpj.16130","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T07:26:08Z","timestamp":1675236368000},"page":"193-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The transcription factor <scp>MYC1<\/scp> interacts with <scp>FIT<\/scp> to negatively regulate iron homeostasis in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"114","author":[{"given":"Hui","family":"Song","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei 230009 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