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However, the mechanism through which plants develop and retain infection memory is not known. Experiments have shown the association of epigenetic modifications of specific defense\u2010related genes with SAR. <jats:italic>RSI1<\/jats:italic>\/<jats:italic>FLD<\/jats:italic> codes for a histone demethylase and is required for the activation of SAR in Arabidopsis. Here we report the identification of <jats:italic>RRTF1<\/jats:italic> as an epigenetic target of RSI1. <jats:italic>RRTF1<\/jats:italic> expression is higher in pathogen\u2010free distal tissues of the <jats:italic>rsi1<\/jats:italic> mutant. Experiments with loss\u2010of\u2010function and overexpression lines suggest RRTF1 is a negative regulator of basal defense against virulent and avirulent pathogens as well as SAR. Enhanced expression of <jats:italic>RRTF1<\/jats:italic> in a wild\u2010type (WT) background specifically impairs SAR without impacting local resistance. RSI1 is recruited at the <jats:italic>RRTF1<\/jats:italic> locus in a SAR\u2010inducible manner and contributes to H3K4me2 and H3K4me3 demethylation. Introduction of the <jats:italic>rrtf1<\/jats:italic> mutation rescues the loss\u2010of\u2010SAR phenotype of <jats:italic>rsi1<\/jats:italic> plants. However, these plants fail to retain infection memory beyond 7\u2009days post\u2010primary inoculation, whereas WT plants retain memory for at least 11\u2009days. Our results demonstrate that <jats:italic>RSI1<\/jats:italic> and <jats:italic>RRTF1<\/jats:italic> form a functional module for retaining infection memory in Arabidopsis.<\/jats:p>","DOI":"10.1111\/tpj.16252","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T13:27:59Z","timestamp":1682429279000},"page":"662-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>RSI1<\/scp>\/<scp>FLD<\/scp> and its epigenetic target <scp><i>RRTF1<\/i><\/scp> are essential for the retention of infection memory in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"115","author":[{"given":"Deepjyoti","family":"Singh","sequence":"first","affiliation":[{"name":"School of Life Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Patil","sequence":"additional","affiliation":[{"name":"School of Life 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