{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:23:10Z","timestamp":1790202190482,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EUR\u20100007"],"award-info":[{"award-number":["ANR\u201017\u2010EUR\u20100007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    The secretory pathway is essential for plant immunity, delivering diverse antimicrobial molecules into the extracellular space.\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    soluble N\u2010ethylmaleimide\u2010sensitive\u2010factor attachment protein receptor SNAP33 is a key actor of this process. The\n                    <jats:italic>snap33<\/jats:italic>\n                    mutant displays dwarfism and necrotic lesions, however the molecular determinants of its macroscopic phenotypes remain elusive. Here, we isolated several new\n                    <jats:italic>snap33<\/jats:italic>\n                    mutants that exhibited constitutive cell death and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    accumulation, further defining\n                    <jats:italic>snap33<\/jats:italic>\n                    as an autoimmune mutant. We then carried out quantitative transcriptomic and proteomic analyses showing that numerous defense transcripts and proteins were up\u2010regulated in the\n                    <jats:italic>snap33<\/jats:italic>\n                    mutant, among which genes\/proteins involved in defense hormone, pattern\u2010triggered immunity, and nucleotide\u2010binding domain leucine\u2010rich\u2010repeat receptor signaling. qRT\u2010PCR analyses and hormone dosages supported these results. Furthermore, genetic analyses elucidated the diverse contributions of the main defense hormones and some nucleotide\u2010binding domain leucine\u2010rich\u2010repeat receptor signaling actors in the establishment of the\n                    <jats:italic>snap33<\/jats:italic>\n                    phenotype, emphasizing the preponderant role of salicylic acid over other defense phytohormones. Moreover, the accumulation of pattern\u2010triggered immunity and nucleotide\u2010binding domain leucine\u2010rich\u2010repeat receptor signaling proteins in the\n                    <jats:italic>snap33<\/jats:italic>\n                    mutant was confirmed by immunoblotting analyses and further shown to be salicylic acid\u2010dependent. Collectively, this study unveiled molecular determinants underlying the Arabidopsis\n                    <jats:italic>snap33<\/jats:italic>\n                    mutant phenotype and brought new insights into autoimmunity signaling.\n                  <\/jats:p>","DOI":"10.1111\/tpj.16647","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T11:09:16Z","timestamp":1706440156000},"page":"1016-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated multi\u2010omics and genetic analyses reveal molecular determinants underlying Arabidopsis\n                    <i>snap33<\/i>\n                    mutant phenotype"],"prefix":"10.1111","volume":"118","author":[{"given":"Houda","family":"Henchiri","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, CNRS, INRAE, Universit\u00e9 Evry, Institute of Plant Sciences Paris\u2010Saclay (IPS2)  91190 Gif\u2010sur\u2010Yvette France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, CNRS, INRAE, Institute of Plant Sciences Paris\u2010Saclay (IPS2)  91190 Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-3735","authenticated-orcid":false,"given":"Naganand","family":"Rayapuram","sequence":"additional","affiliation":[{"name":"Division of Biological and Environmental Sciences and Engineering King Abdullah University of Science and Technology  Thuwal 23955 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna M.","family":"Alhoraibi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science King Abdulaziz University  21551 Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ca\u00efus","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, CNRS, INRAE, 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