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Here, we show that the regulation of <jats:italic>TEOSINTE BRANCHED1\/CYCLOIDEA\/PCF (TCP) LANCEOLATE<\/jats:italic> (<jats:italic>TCP2\/LA<\/jats:italic>) by miR319 is crucial for tomato fruit morphology. The loss of miR319 regulation in the semi\u2010dominant <jats:italic>La<\/jats:italic> mutant led to a premature <jats:italic>SlTCP2\/LA<\/jats:italic> expression during gynoecium patterning, which results in modified cell division during carpel development. As a consequence, <jats:italic>La<\/jats:italic> mutants exhibited elongated ovary and fruit shape, and a reduced number of ovules and seeds. Elongated fruit shape in <jats:italic>La<\/jats:italic> may be partially due to the <jats:italic>SlTCP2\/LA<\/jats:italic>\u2010mediated repression of <jats:italic>OVATE<\/jats:italic> activity in young floral buds. Further analysis showed that the de\u2010repression of <jats:italic>SlTCP2\/LA<\/jats:italic> decreases auxin responses in young floral buds by directly repressing <jats:italic>SlYUCCA4<\/jats:italic> expression, but <jats:italic>SlTCP2\/LA<\/jats:italic> also acts in parallel with <jats:italic>ENTIRE<\/jats:italic> (<jats:italic>E<\/jats:italic>) to orchestrate fruit morphology and seed production. Our study defines a novel miRNA\u2010based molecular link between the domestication\u2010associated <jats:italic>OVATE<\/jats:italic> gene and auxin responses. Given the striking variation in fruit morphology among members of the Solanaceae family, fine\u2010tuning regulation of gene expression by miRNA coupled with modulation of auxin dynamics may be a common driver in the evolution of fruit shape diversity.<\/jats:p>","DOI":"10.1111\/tpj.17174","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T17:43:42Z","timestamp":1732643022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The <scp>miR319<\/scp>\u2010based repression of <scp>SlTCP2<\/scp>\/<scp>LANCEOLATE<\/scp> activity is required for regulating tomato fruit shape"],"prefix":"10.1111","volume":"121","author":[{"suffix":"Jr","given":"Airton","family":"Carvalho","sequence":"first","affiliation":[{"name":"Escola Superior de Agricultura \u201cLuiz de Queiroz\u201d (ESALQ) Universidade de S\u00e3o Paulo  13418\u2010900 Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus H.","family":"Vicente","sequence":"additional","affiliation":[{"name":"Escola Superior de Agricultura \u201cLuiz de Queiroz\u201d (ESALQ) Universidade de S\u00e3o Paulo  13418\u2010900 Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia F.","family":"Ferigolo","sequence":"additional","affiliation":[{"name":"Escola Superior de Agricultura \u201cLuiz de Queiroz\u201d (ESALQ) Universidade de S\u00e3o Paulo  13418\u2010900 Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Escola Superior de Agricultura \u201cLuiz de Queiroz\u201d (ESALQ) Universidade de S\u00e3o Paulo  13418\u2010900 Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Silvestre","family":"Lira","sequence":"additional","affiliation":[{"name":"Instituto de Bioci\u00eancias Universidade de S\u00e3o Paulo  S\u00e3o Paulo 05508\u2010090 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naama","family":"Teboul","sequence":"additional","affiliation":[{"name":"The Robert H. 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