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Although several genes have been identified that enhance the ability of rice to withstand drought stress, further research is needed to fully understand the molecular mechanisms underlying the response to drought stress. Our study showed that overexpression of rice <jats:italic>DNA binding with one finger 12<\/jats:italic> (<jats:italic>OsDof12<\/jats:italic>) enhances tolerance to drought stress. Rice plants overexpressing <jats:italic>OsDof12<\/jats:italic> (<jats:italic>OsDof12<\/jats:italic>\u2010OE) displayed significantly higher tolerance to drought stress than the parental <jats:italic>japonica<\/jats:italic> rice \u201cDongjin\u201d. Transcriptome analysis revealed that many genes involved in phenylpropanoid biosynthesis were upregulated in <jats:italic>OsDof12<\/jats:italic>\u2010OE plants, including <jats:italic>phenylalanine ammonia\u2010lyase 4<\/jats:italic> (<jats:italic>OsPAL4<\/jats:italic>), <jats:italic>OsPAL6<\/jats:italic>, <jats:italic>cinnamyl alcohol dehydrogenase 6<\/jats:italic> (<jats:italic>CAD6<\/jats:italic>), and <jats:italic>4\u2010coumarate\u2010coA ligase like 6<\/jats:italic> (<jats:italic>4CLL6<\/jats:italic>). Accordingly, this transcriptional alteration led to the substantial accumulation of phenolic compounds, such as sinapic acids, in the leaves of <jats:italic>OsDof12<\/jats:italic>\u2010OE plants, effectively lowering the levels of reactive oxygen species. Notably, OsDof12 bound to the AAAG\u2010rich core sequence of the <jats:italic>OsPAL4<\/jats:italic> promoter and promoted transcription. In addition, GIGANTEA (OsGI) interacts with OsDof12 in the nucleus and attenuates the transactivation activity of OsDof12 on <jats:italic>OsPAL4<\/jats:italic>. Our findings reveal a novel role for <jats:italic>OsDof12<\/jats:italic> in promoting phenylpropanoid\u2010mediated tolerance to drought stress.<\/jats:p>","DOI":"10.1111\/tpj.17175","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T16:15:36Z","timestamp":1732983336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Rice <i>OsDof12<\/i> enhances tolerance to drought stress by activating the phenylpropanoid pathway"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-2760","authenticated-orcid":false,"given":"Yejin","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Agriculture, Forestry and Bioresources, Research Institute of Agriculture and Life Sciences Seoul National University  Seoul Republic of Korea"},{"name":"Plant Genomics and Breeding Institute Seoul National University  Seoul Republic of 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