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In order to maintain genome integrity DNA repair pathways must be efficiently activated to prevent mutations and deleterious chromosomal rearrangements. Conversely, genome rearrangement is also necessary to allow genetic diversity and evolution. The antagonist interaction between maintenance of genome integrity and rearrangements determines genome shape and organization. Therefore, it is of great interest to understand how the whole linear genome structure behaves upon formation and repair of DNA damage. For this, we used long reads sequencing technology to identify and to characterize genomic structural variations (SV) of wild\u2010type <jats:italic>Arabidopsis thaliana<\/jats:italic> somatic cells exposed either to UV\u2010B, to UV\u2010C or to protons irradiations. We found that genomic regions located in heterochromatin are more prone to form SVs than those located in euchromatin, highlighting that genome stability differs along the chromosome. This holds true in Arabidopsis plants deficient for the expression of master regulators of the DNA damage response (DDR), ATM (Ataxia\u2010telangiectasia\u2010mutated) and ATR (Ataxia\u2010telangiectasia\u2010mutated and Rad3\u2010related), suggesting that independent and alternative surveillance processes exist to maintain integrity in genic regions. Finally, the analysis of the radiations\u2010induced deleted regions allowed determining that exposure to UV\u2010B, UV\u2010C and protons induced the microhomology\u2010mediated end joining mechanism (MMEJ) and that both ATM and ATR repress this repair pathway.<\/jats:p>","DOI":"10.1111\/tpj.17180","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T17:04:09Z","timestamp":1733072649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of radiations\u2010induced genomic structural variations in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"121","author":[{"given":"Salimata Ousmane","family":"Sall","sequence":"first","affiliation":[{"name":"Institut de biologie mol\u00e9culaire des plantes du CNRS  12 rue du G\u00e9n\u00e9ral Zimmer 67000 Strasbourg 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