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Previously, we generated transgenic rice plants with altered lignin aromatic composition and enhanced biomass utilization properties by suppressing the expression of p\u2010\n                    <jats:italic>COUMAROYL ESTER 3\u2010HYDROXYLASE<\/jats:italic>\n                    (\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    ). While RNAi\u2010derived\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockdown lines displayed relatively normal growth with substantially augmented levels of\n                    <jats:italic>p<\/jats:italic>\n                    \u2010hydroxyphenyl\u2010type lignin units, genome\u2010edited\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockout lines exhibited severely impaired growth phenotype, leading to arrested seedling development. In this study, we further characterized the genome\u2010edited\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockout rice by analyzing gene expression and phenolic metabolite profiles alongside phenotypic traits and cell wall lignin structure. The seedlings of the\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockout rice displayed irregular vasculature and ectopic lignification. RNA\u2010sequencing analysis detected widespread changes in the expression of genes associated with plant growth, hormone biosynthesis and signaling, and stress responses in the\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockout rice. Overall, our data suggested that\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    disruption activates metabolic sensor\u2010mediated signaling pathways, which in turn regulate phenylpropanoid metabolism. In line with this, phenolic metabolite profiling of the\n                    <jats:italic>C3\u2032H<\/jats:italic>\n                    \u2010knockout rice revealed not only shifts in monolignol\u2010associated phenylpropanoids but also reductions in flavonoids and salicylic acid derivatives. Moreover, changes in the aromatic composition of the mutant lignin and phenolic metabolites indicated the presence of parallel monolignol pathways enabling rice to produce guaiacyl\u2010 and syringyl\u2010type monolignol derivatives in the absence of C3\u2032H activity. Our findings contribute to a deeper understanding of the mechanisms underlying the growth defects of lignin\u2010modified mutants, with implications for optimizing the utility of grass lignocellulose.\n                  <\/jats:p>","DOI":"10.1111\/tpj.70039","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:15:14Z","timestamp":1741738514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered development and lignin deposition in rice p\u2010\n                    <i>COUMAROYL ESTER 3\u2010HYDROXYLASE<\/i>\n                    loss\u2010of\u2010function mutants"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-8459","authenticated-orcid":false,"given":"Yuri","family":"Takeda\u2010Kimura","sequence":"first","affiliation":[{"name":"Research Institute for Sustainable Humanosphere Kyoto University  Gokasho, Uji Kyoto 611\u20100011 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