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Previous studies by our group revealed that NO delays flowering in Arabidopsis by increasing transcript levels of the flowering repressor\n                    <jats:italic>FLOWERING LOCUS C<\/jats:italic>\n                    (\n                    <jats:italic>FLC<\/jats:italic>\n                    ). In this study, we further investigated the molecular mechanism by which NO regulates\n                    <jats:italic>FLC<\/jats:italic>\n                    expression. Genetic experiments demonstrated that NO\u2010induced delayed flowering specifically depends on elevated\n                    <jats:italic>FLC<\/jats:italic>\n                    transcript levels. Chromatin Immunoprecipitation assays revealed that NO significantly enhances histone H3 acetylation at the\n                    <jats:italic>FLC<\/jats:italic>\n                    locus. Biochemical analyses further showed that NO reduces total histone deacetylase activity through\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosylation of histone deacetylases HDA5 and HDA6. Additionally, we identified and evaluated potential\n                    <jats:italic>S\u2010<\/jats:italic>\n                    nitrosylation sites on HDA5 and HDA6, revealing their effects on deacetylase activity and floral regulation. Collectively, our findings uncover a novel mechanism by which NO mediates epigenetic modification to modulate flowering in Arabidopsis. This study sheds light on the functional network linking NO signaling, epigenetic modification, and flowering.\n                  <\/jats:p>","DOI":"10.1111\/tpj.70379","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:12:38Z","timestamp":1753773158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nitric oxide delays floral transition in Arabidopsis by inhibiting histone deacetylases\n                    <scp>HDA5<\/scp>\n                    and\n                    <scp>HDA6<\/scp>"],"prefix":"10.1111","volume":"123","author":[{"given":"Wenwen","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Life Sciences Capital Normal University  Beijing 100048 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shihezi University  Shihezi 832003 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzheng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Capital Normal University  Beijing 100048 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology Chinese Academy of Sciences  Beijing 100101 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtian","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Life Sciences Capital Normal University  Beijing 100048 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Life Sciences Capital Normal University  Beijing 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