{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:25:42Z","timestamp":1781173542079,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Plants actively suppress growth and development upon activation of immunity. In turn, when pathogen attack has subsided, immune responses are suppressed again. Phytohormones play an important role in regulating this balance and the growth\u2013immunity trade\u2010off in general. The trade\u2010off is evident in the Arabidopsis\n                    <jats:italic>dmr6 dlo1<\/jats:italic>\n                    mutant, which accumulates the immune\u2010activating phytohormone salicylic acid (SA) to high levels, resulting in high disease resistance but repression of growth. Little is known about the SA\u2010induced growth trade\u2010off mechanism. In this study, we performed a genetic suppressor screen on the\n                    <jats:italic>dmr6 dlo1<\/jats:italic>\n                    double mutant to select mutants with reduced growth repression and identify suppressors of the SA\u2010mediated trade\u2010off. We identified 7 independent\n                    <jats:italic>zund<\/jats:italic>\n                    (\n                    <jats:italic>giant<\/jats:italic>\n                    ) mutants, with restored growth but retained resistance to downy mildew. Through bulked segregant analysis and whole\u2010genome sequencing (BSA\u2010seq), we identified three mutant alleles of\n                    <jats:italic>MED15a<\/jats:italic>\n                    , an\n                    <jats:italic>NPR1<\/jats:italic>\n                    allele, one\n                    <jats:italic>ICS1\/SID2<\/jats:italic>\n                    allele, and a\n                    <jats:italic>PAD4<\/jats:italic>\n                    splice defect. Genetic complementation of mutants confirmed the roles of these genes in the SA\u2010mediated growth\u2013immunity trade\u2010off. We discuss their application in tweaking SA signaling to optimize the balance between growth and immunity that is important when deploying immunity traits in breeding.\n                  <\/jats:p>","DOI":"10.1111\/tpj.70467","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T19:18:36Z","timestamp":1758309516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic suppressors of the growth\u2010immunity trade\u2010off in the Arabidopsis salicylic acid\u2010accumulating\n                    <i>dmr6 dlo1<\/i>\n                    mutant"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-3981","authenticated-orcid":false,"given":"Tijmen","family":"van Butselaar","sequence":"first","affiliation":[{"name":"Translational Plant Biology, Department of Biology Institute of Environmental Biology  Padualaan 8 3584 CH Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2088-2378","authenticated-orcid":false,"given":"Tom","family":"Schermer","sequence":"additional","affiliation":[{"name":"Translational Plant Biology, Department of Biology Institute of Environmental Biology  Padualaan 8 3584 CH Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Bijlmer","sequence":"additional","affiliation":[{"name":"Translational Plant Biology, Department of Biology Institute of Environmental Biology  Padualaan 8 3584 CH Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Elberse","sequence":"additional","affiliation":[{"name":"Translational Plant Biology, Department of Biology Institute of Environmental Biology  Padualaan 8 3584 CH Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3395-9312","authenticated-orcid":false,"given":"Chris","family":"van Schie","sequence":"additional","affiliation":[{"name":"Enza Zaden, Haling 1\u2010E  1602 DB Enkhuizen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-8978","authenticated-orcid":false,"given":"Guido","family":"Van den Ackerveken","sequence":"additional","affiliation":[{"name":"Translational Plant Biology, Department of Biology Institute of Environmental Biology  Padualaan 8 3584 CH Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"725","article-title":"Should I fight or should I grow now? 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