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Here, we identify WPR, a unique P\u2010type PPR protein in rice (\n                    <jats:italic>Oryza sativa<\/jats:italic>\n                    L.), as a critical factor in chloroplast RNA splicing and editing. A ~112\u2010kb chromosomal inversion upstream of WPR causes an albino panicle rachis phenotype (\n                    <jats:italic>wpr<\/jats:italic>\n                    mutant), while complete loss of WPR function leads to seedling lethality. WPR deficiency disrupts the splicing of multiple group II introns (atpF, ndhA, ndhB, petB, rpl2, and rps12) and impairs RNA editing in transcripts such as ndhA, ndhB, ndhG, rps14, and ycf3. Electrophoretic mobility shift assay (EMSA) data confirm that WPR directly binds to precursor mRNAs of atpF, ndhA, petB, rpl2, and rps12. Strikingly, WPR interacts with both RNA editing factors (MORF1, MORF8b) and the splicing factor CAF2, but not with other PPR proteins targeting the same transcripts. Unlike most PPR proteins, WPR contains only six PPR repeats, which is the fewest among all functionally characterized rice PPR proteins. With few informative repeats, WPR likely possesses a broad, low\u2010specificity RNA\u2010binding activity. Moreover, WPR may act on chloroplast RNA maturation by recruiting MORFs and CAF2 rather than other PPR proteins, highlighting a novel regulatory mode in which P\u2010type PPR protein may act as an RNA\u2010binding scaffold to integrate diverse RNA\u2010processing machineries. This study advances the understanding of PPR protein diversity and provides new insights into the molecular mechanisms of chloroplast RNA processing in rice.\n                  <\/jats:p>","DOI":"10.1111\/tpj.70526","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T23:10:12Z","timestamp":1761261012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A six\u2010repeat\n                    <scp>PPR<\/scp>\n                    protein\n                    <scp>WPR<\/scp>\n                    directly binds target\n                    <scp>RNAs<\/scp>\n                    and coordinates chloroplast\n                    <scp>RNA<\/scp>\n                    processing via dual recruitment of\n                    <scp>MORF1<\/scp>\n                    ,\n                    <scp>MORF8b<\/scp>\n                    , and\n                    <scp>CAF2<\/scp>\n                    proteins in rice"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-4598","authenticated-orcid":false,"given":"Bo","family":"Zhao","sequence":"first","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, CAAS\u2010IRRI Joint Laboratory for Genomics\u2010Assisted Germplasm Enhancement, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences  Shenzhen 518120 China"},{"name":"Shanxi Hou Ji Laboratory, College of Agriculture Shanxi Agricultural University  Taiyuan 030031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, CAAS\u2010IRRI Joint Laboratory for Genomics\u2010Assisted Germplasm Enhancement, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences  Shenzhen 518120 China"},{"name":"State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences  Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, CAAS\u2010IRRI Joint Laboratory for Genomics\u2010Assisted Germplasm Enhancement, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences  Shenzhen 518120 China"},{"name":"State Key Laboratory of Crop Gene Resources and Breeding Chinese Academy of Agricultural Sciences  Beijing 100081 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