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Elucidating the complex mechanisms of cold tolerance in rice is crucial for developing cold\u2010tolerant varieties through molecular breeding. Here, we identified a WRKY transcription factor,\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    , as a positive regulator of cold tolerance in rice.\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    expression was induced by both cold stress and exogenous jasmonic acid (JA) treatment. Genetic evidence showed that\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    overexpression enhanced cold tolerance of rice seedlings, while knockout of\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    reduced cold tolerance. In addition, we demonstrated that under cold stress, OsWRKY11 directly activates both the JA biosynthesis gene\n                    <jats:italic>OsLOX1<\/jats:italic>\n                    and the CBF family members (\n                    <jats:italic>OsDREB1A<\/jats:italic>\n                    ,\n                    <jats:italic>OsDREB1B<\/jats:italic>\n                    , and\n                    <jats:italic>OsDREB1F<\/jats:italic>\n                    ) by binding to W\u2010box motifs in their promoters. Physiological analyses showed that\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    promotes JA biosynthesis and enhances reactive oxygen species (ROS) scavenging under cold stress. This elevated JA level, in turn, upregulates\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    expression and thereby creates a positive feedback loop that amplifies cold stress signaling. Furthermore, cold stress assays with MeJA and JA synthesis inhibitor ibuprofen suggested that\n                    <jats:italic>OsWRKY11<\/jats:italic>\n                    functions in the JA\u2010mediated cold signaling pathway. Finally, biochemical analyses demonstrated that OsICE1 physically interacts with OsWRKY11, forming a synergistic complex that enhances the transcriptional activation and DNA\u2010binding ability of OsWRKY11. Taken together, our results strongly suggest that the OsWRKY11\u2013OsICE1 module orchestrates cold tolerance in rice by integrating ROS accumulation with the JA and CBF signaling pathways. This regulatory module provides promising targets for the molecular breeding of cold\u2010tolerant rice varieties.\n                  <\/jats:p>","DOI":"10.1111\/tpj.70894","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:00:55Z","timestamp":1776974455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The transcription factor\n                    <i>OsWRKY11<\/i>\n                    orchestrates rice cold tolerance through integrating multiple signaling pathways"],"prefix":"10.1111","volume":"126","author":[{"given":"Yao","family":"Wan","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Agro\u2010environment and Agro\u2010products Safety, College of Agriculture Guangxi University  Nanning 530004 Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key 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