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Although the enzymes such as uridine diphosphate (UDP)\u2010glucose dehydrogenase (UGD) involved in nucleotide sugar biosynthesis have been biochemically characterized, their biological roles in plants remain largely unexplored. In this study, we identify a rice mutant\n                    <jats:italic>weakness and root hair defective 1<\/jats:italic>\n                    (\n                    <jats:italic>wrd1<\/jats:italic>\n                    ), which exhibits pleiotropic phenotypes including dwarfism, reduced tiller number, and abnormal root architecture.\n                    <jats:italic>WRD1<\/jats:italic>\n                    encodes a UGD that catalyzes the conversion of UDP\u2010Glc to UDP\u2010GlcA. The\n                    <jats:italic>WRD1<\/jats:italic>\n                    mutation disrupts this enzymatic function and substantially reduces UGD activity\n                    <jats:italic>in vivo<\/jats:italic>\n                    , resulting in elevated UDP\u2010Glc accumulation, decreased UDP\u2010GlcA levels, and consequently an imbalance in their downstream derivatives. The aberrant UDP\u2010sugar metabolism significantly impairs cell wall architecture and auxin glycosylation in the\n                    <jats:italic>wrd1<\/jats:italic>\n                    mutant, accompanied by dysregulated reactive oxygen species (ROS) homeostasis and auxin\u2010related gene expression. These combined effects lead to excessive ROS production and abnormal auxin signaling in root cells, resulting in programmed cell death and severe developmental defects. Our findings highlight the critical role of WRD1 in regulating cell wall formation and overall plant growth by modulating nucleotide sugars homeostasis, which provides new insights into the interplay between cell wall biosynthesis, auxin signaling, and ROS metabolism during plant development.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71004","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:57:53Z","timestamp":1783551473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dehydrogenase\n                    <scp>WRD1<\/scp>\n                    regulates plant growth by modulating cell wall formation,\n                    <scp>ROS<\/scp>\n                    homeostasis, and auxin signaling in rice"],"prefix":"10.1111","volume":"127","author":[{"given":"Fei","family":"Chen","sequence":"first","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Rice Biology China National Rice Research Institute  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences, Hangzhou Normal University  Zhejiang 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