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Genetically, tuberization in potato is controlled by\n                    <jats:italic>FLOWERING LOCUS T<\/jats:italic>\n                    (\n                    <jats:italic>FT<\/jats:italic>\n                    ) homologs. However, from non\u2010tuberous ancestors to potato, what remodeling of these tuber formation determinants emerged remains unclear. Using homology\u2010based discovery, expression profiling, CRISPR knockouts, and genetic complementation, we here show that tuberization\u2010controlling\n                    <jats:italic>FT\u2010like<\/jats:italic>\n                    genes underwent Petota\u2010specific expansion, restructuring, and divergence at key functional residues. We found that short day\u2010induced\n                    <jats:italic>SeSP5G<\/jats:italic>\n                    expression inhibited flowering of Etuberosum, a non\u2010tuberous ancestor. This thereby defines it as a long\u2010day plant (LDP) and suggests that the short day\u2010dependent tuberization of potatoes was likely an inheritance from Tomato. Importantly, by expressing the potato tuber\u2010forming gene\n                    <jats:italic>StSP6A<\/jats:italic>\n                    in\n                    <jats:italic>Solanum etuberosum<\/jats:italic>\n                    , which forms underground stems but is hypothesized to lack tubers from pseudogenization of the\n                    <jats:italic>SeSP6A<\/jats:italic>\n                    gene, we show that the complementation of\n                    <jats:italic>StSP6A<\/jats:italic>\n                    promotes floral transition in Etuberosum yet fails to induce tuber development. Thus, it is indicated that the key genetic determinants enabling tuberization downstream of\n                    <jats:italic>SP6A<\/jats:italic>\n                    diverge between Petota and Etuberosum. These studies identify key renovations in\n                    <jats:italic>FT\u2010like<\/jats:italic>\n                    genes that facilitate the recruitment of the florigenic signaling for tuberization, exemplifying speciation\u2010driven functional innovation in a widely conserved gene.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71044","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:45:41Z","timestamp":1783917941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remodeling of the tuberization\u2010controlling\n                    <i>FLOWERING LOCUS T<\/i>\n                    genes from non\u2010tuberizing ancestor to potato"],"prefix":"10.1111","volume":"127","author":[{"given":"Miao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal University  Chengdu 610101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal University  Chengdu 610101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal University  Chengdu 610101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal University  Chengdu 610101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-9121","authenticated-orcid":false,"given":"Zixian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant Functional Genomics and Bioinformatics Research Center Sichuan Normal University  Chengdu 610101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-6673","authenticated-orcid":false,"given":"Shenglin","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences Sichuan Normal University  Chengdu 610101 China"},{"name":"Plant 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