{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:07:09Z","timestamp":1788973629875,"version":"build-2803163510"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020K2A9A2A06051940"],"award-info":[{"award-number":["2020K2A9A2A06051940"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C3011104"],"award-info":[{"award-number":["2021R1A2C3011104"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Leaf senescence, the final stage of leaf development, is regulated by complex interplays of intrinsic genetic programs and environmental cues. Throughout their lifetimes, all living organisms encounter various endogenous and environmental challenges, many of which can cause potentially fatal DNA damage. Among these, DNA\u2010protein crosslinks (DPCs) are particularly deleterious, as they obstruct essential processes such as replication and transcription, thereby compromising genome integrity and ultimately leading to premature aging across species. However, the biological significance of DPCs and their repair mechanisms in leaf senescence remains unexplored. Here, we demonstrate that cis\u2010platin (cis\u2010Pt), a potent DPC inducer, accelerates leaf senescence in Arabidopsis. We reveal that Arabidopsis DPC repair factor WSS1A, a WLM\/Spr\u2010T metalloprotease, plays a negative role in leaf senescence induced by cis\u2010Pt treatment, darkness, and leaf age. WSS1A forms nuclear condensates via liquid\u2013liquid phase separation both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , which is cooperatively driven by its N\u2010terminal segment and intrinsically disordered region. Mechanistically, WSS1A non\u2010covalently interacts with SMALL UBIQUITIN MODIFIER 3 (SUMO3) through its SUMO\u2010interacting motif and is also covalently SUMOylated by SUMO3. Genetic analysis further reveals that WSS1A and SUMO3 act in the same pathway to control cis\u2010Pt\u2010induced leaf senescence. Together, this study establishes a conceptual framework connecting DPC repair and SUMO3\u2010dependent regulation of WSS1A in modulating leaf senescence in Arabidopsis.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71094","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:49:50Z","timestamp":1787424590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arabidopsis\n                    <scp>WSS1A<\/scp>\n                    , a\n                    <scp>DNA<\/scp>\n                    \u2010protein crosslink repair protease, delays leaf senescence in cooperation with\n                    <scp>SUMO3<\/scp>"],"prefix":"10.1111","volume":"127","author":[{"given":"Sanghoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of New Biology Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 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