{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:56:53Z","timestamp":1791446213413,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472512"],"award-info":[{"award-number":["32472512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272556"],"award-info":[{"award-number":["32272556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018570","name":"Special Project of Central Government for Local Science and Technology Development of Hubei Province","doi-asserted-by":"publisher","award":["2024CSA060"],"award-info":[{"award-number":["2024CSA060"]}],"id":[{"id":"10.13039\/501100018570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662025ZKPY008"],"award-info":[{"award-number":["2662025ZKPY008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Bacterial wilt caused by\n                    <jats:italic>Ralstonia solanacearum<\/jats:italic>\n                    is a devastating disease that affects a wide range of crops, including tobacco. The pathogen promotes infection by secreting type III effector (T3E) proteins into host plants to facilitate pathogenicity; however, the molecular mechanisms for many of these effectors remain elusive. Here, we characterize RipAD, a conserved T3E that significantly contributes to\n                    <jats:italic>R. solanacearum<\/jats:italic>\n                    virulence in\n                    <jats:italic>Nicotiana tabacum<\/jats:italic>\n                    and\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    . We demonstrate that RipAD dampens early immune responses, including pathogen\u2010associated molecular pattern\u2010triggered reactive oxygen species (ROS) bursts and MAPK activation. This immunosuppressive function depends on the dual localization of RipAD to the plasma membrane and the nucleus. Mechanistically, RipAD physically associates with the N\u2010terminal domains of the plasma membrane intrinsic proteins NbPIP2;3 and NbPIP2;4. We show that these aquaporins act as positive regulators of ROS accumulation and plant immunity. Crucially, RipAD binding is associated with reduced homo\u2010 and hetero\u2010oligomerization of NbPIP2;3 and NbPIP2;4, thereby compromising their stability and function. Furthermore, silencing\n                    <jats:italic>NbPIP2;3<\/jats:italic>\n                    and\n                    <jats:italic>NbPIP2;4<\/jats:italic>\n                    increases tobacco susceptibility and rescues the virulence defect of a RipAD deletion mutant. These findings reveal a novel virulence strategy wherein a bacterial effector targets the structural integrity of host aquaporin complexes to block ROS signaling and suppress immunity.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71111","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:46:39Z","timestamp":1791445599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <i>Ralstonia solanacearum<\/i>\n                    effector\n                    <scp>RipAD<\/scp>\n                    perturbs aquaporin\n                    <scp>NbPIP<\/scp>\n                    oligomeric status to suppress plant immunity"],"prefix":"10.1111","volume":"128","author":[{"given":"Bo","family":"Nian","sequence":"first","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-2265","authenticated-orcid":false,"given":"Pengyue","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-7063","authenticated-orcid":false,"given":"Yang","family":"Lin","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-0338","authenticated-orcid":false,"given":"Jiatao","family":"Xie","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-2360","authenticated-orcid":false,"given":"Jiasen","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-7431","authenticated-orcid":false,"given":"Yanping","family":"Fu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-3075","authenticated-orcid":false,"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-7461","authenticated-orcid":false,"given":"Daohong","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-0112","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University  Wuhan Hubei 430070 China"},{"name":"Hubei Hongshan Laboratory  Wuhan Hubei 430070 China"},{"name":"The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and Technology, Huazhong Agricultural University  Wuhan Hubei 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/jdb4010009","article-title":"The roles of aquaporins in plant stress responses","volume":"4","author":"Afzal Z.","year":"2016","journal-title":"Journal of Developmental Biology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1104\/pp.118.1.315","article-title":"Distinct biochemical and topological properties of the 31\u2010 and 27\u2010kilodalton plasma membrane intrinsic protein subgroups from red beet","volume":"118","author":"Barone L.M.","year":"1998","journal-title":"Plant 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solanacearum type III effectors and their in planta functions","volume":"21","author":"Landry D.","year":"2020","journal-title":"Molecular Plant Pathology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.3390\/plants9091134","article-title":"Roles of aquaporins in plant\u2010pathogen interaction","volume":"9","author":"Li G.","year":"2020","journal-title":"Plants"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.chom.2014.02.009","article-title":"The FLS2\u2010associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity","volume":"15","author":"Li L.","year":"2014","journal-title":"Cell Host & Microbe"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116390","article-title":"Specific phosphorylation at Ser60 in N terminus of SlCAK1 propels bacterial cold shock protein\u2010induced immunity in plants","volume":"44","author":"Li 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