{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:06:13Z","timestamp":1789729573296,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024ZD20"],"award-info":[{"award-number":["2024ZD20"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    The typical nucleotide\u2010binding leucine\u2010rich repeat (NLR) proteins, such as TIR\u2010NBS\u2010LRR (TNL) and CC\u2010NBS\u2010LRR (CNL), are known to be engaged in effector\u2010triggered immunity (ETI). However, several atypical resistance (R) proteins with truncated NLR domains or with nonclassical domains are emerging to be key regulators in plant immunity. SMV resistance cluster 4 (SRC4) is an atypical NLR protein in soybean, distinguished by an N\u2010terminal Domain (NTD)\u2010TIR\u2010shortened NBS oligomerization region (SNOR)\u2010EF\u2010hand (EFh) domain architecture. SRC4 lacks both NBS and LRR domains but retains basal antiviral activity through its TIR\u2010SNOR region, with SNOR contributing to TIR\u2010dependent antiviral activity and SRC4 self\u2010association. The EFh domain recognizes coat protein (CP) of soybean mosaic virus (SMV) and serves as a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010responsive module to distinctly regulate TIR\u2010SNOR\u2010mediated immune response in soybean.\n                    <jats:italic>SRC4\u2010<\/jats:italic>\n                    overexpression (Ox\u2010\n                    <jats:italic>SRC4<\/jats:italic>\n                    ) soybean plants show SMV resistance without obvious growth penalty. Furthermore, several\n                    <jats:italic>SRC4<\/jats:italic>\n                    high\u2010expression soybean varieties showed stronger SMV resistance and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responsiveness than the\n                    <jats:italic>SRC4<\/jats:italic>\n                    low\u2010expression soybean varieties. Our study highlights the essential roles of atypical resistance proteins in plant immunity and growth\u2010defense balance.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71125","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:20:33Z","timestamp":1789460433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An atypical\n                    <scp>EF<\/scp>\n                    \u2010hand domain containing resistance protein\n                    <scp>SRC4<\/scp>\n                    boosts plant immunity in a calcium\u2010enhanced manner"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-1527","authenticated-orcid":false,"given":"Zikai","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Forage and Endemic Crop Biology, Ministry of Education, School of Life Sciences Inner Mongolia University  Hohhot 010070 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