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Comprehensive metabolite analyses reveal that SARD1\/CBP60g exert distinct influences on major stress\u2010inducible metabolic pathways. The SARD1\/CBP60g transcriptional node decisively boosts the biosynthesis of the systemic acquired resistance (SAR)\u2010inducing metabolites N\u2010hydroxypipecolic acid (NHP) and salicylic acid (SA), as well as their metabolism to major glucose conjugates. Additionally, it significantly promotes the biotic stress\u2010induced accumulation of aromatic and branched\u2010chain amino acids, and the generation of the antioxidant \u03b3\u2010tocopherol. By contrast, SARD1\/CBP60g does not impact or yet exerts negative influence on the stress\u2010induced biosynthesis of indolic defense compounds, including the phytoalexin camalexin, accumulation of Lys, Ser and Gly, and sterol desaturation. Significantly, we show that SARD1\/CBP60g also acts downstream of NHP and SA in immune signaling, indicating a critical function of this transcriptional node in an NHP\u2010 and SA\u2010driven immune amplification relay operating in SAR. RNA\u2010sequencing analysis highlight that the transcriptional response to NHP is separable into two gene groups with different regulatory characteristics. One group consists of strongly SARD1\/CBP60g\u2010promoted genes that invariably contain NHP and SA\u2010pathway genes and is enriched in SA\u2010inducible genes. Genes of the other group, which overrepresents H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010inducible genes and concentrates genes of indolic metabolism, are not promoted by SARD1\/CBP60g. Interestingly, SARD1\/CBP60g oppositely affect the NHP\u2010mediated priming of pathogen\u2010induced SA and camalexin biosynthesis as well, illustrating that plants realize priming of distinct defenses by different mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71130","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:40:26Z","timestamp":1790055626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SARD1<\/scp>\n                    and\n                    <scp>CBP60g<\/scp>\n                    redundantly regulate N\u2010hydroxypipecolic acid\u2010 and salicylic acid\u2010dependent systemic immunity but are dispensable for the activation of indolic defense metabolism"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8871-4492","authenticated-orcid":false,"given":"Mona","family":"Perrar","sequence":"first","affiliation":[{"name":"Department of Biology, Institute for Molecular Ecophysiology of Plants Heinrich Heine University  Universit\u00e4tsstra\u00dfe 1 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute for Molecular Ecophysiology of Plants Heinrich Heine University  Universit\u00e4tsstra\u00dfe 1 D\u00fcsseldorf D\u201040225 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-5524","authenticated-orcid":false,"given":"Patrick","family":"Petzsch","sequence":"additional","affiliation":[{"name":"Biological and Medical Research Center (BMFZ), Medical Faculty Heinrich Heine University  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