{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:12:22Z","timestamp":1790079142783,"version":"4.0.1"},"reference-count":97,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300314"],"award-info":[{"award-number":["32300314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Apricot (\n                    <jats:italic>Prunus armeniaca<\/jats:italic>\n                    L.) is an economically significant fruit crop worldwide with remarkable germplasm diversity, and its fruit quality is primarily determined by key metabolites (e.g., sugars, organic acids, and flavonoids). However, current apricot genome assemblies remain incomplete, with substantial unanchored regions that hamper analyses of genomic evolution and the regulatory mechanisms underlying fruit quality. Here, we generated the first gap\u2010free telomere\u2010to\u2010telomere (T2T)\n                    <jats:italic>de novo<\/jats:italic>\n                    assembly of the\n                    <jats:italic>P. armeniaca<\/jats:italic>\n                    genome (248.3\u2009Mb) and annotated 22\u2009786 protein\u2010coding genes across eight chromosomes. Combined analyses of metabolomic and transcriptomic data, we characterized the transcriptomic and metabolic landscape of apricot across five developmental stages and assigned 3198 metabolites and their co\u2010expressed genes to five functional metabolic\u2010gene modules. DNA methylome profiling further revealed dynamic epigenetic reprogramming during fruit development, characterized by decreases in CG and CHG methylation and an increase in CHH methylation. Notably, higher CHH DNA methylation in promoter regions was associated with the upregulation of leucoanthocyanidin reductase (\n                    <jats:italic>PaLAR<\/jats:italic>\n                    ) and dihydroflavonol 4\u2010reductase (\n                    <jats:italic>PaDFR<\/jats:italic>\n                    ), contributing to anthocyanin biosynthesis during ripening. Moreover, we identified\n                    <jats:italic>PaTT2<\/jats:italic>\n                    as a potential regulator of proanthocyanidin biosynthesis and directly activates\n                    <jats:italic>PaLAR<\/jats:italic>\n                    , as evidenced by Y1H and dual\u2010luciferase assays. Our study sheds light on the epigenetic and metabolic regulatory networks of apricot, serving as a valuable foundation for molecular breeding and genetic enhancement.\n                  <\/jats:p>","DOI":"10.1111\/tpj.71138","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:37:53Z","timestamp":1790077073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The telomere\u2010to\u2010telomere gap\u2010free reference genome and\n                    <scp>DNA<\/scp>\n                    methylome unveil epigenetic regulation of proanthocyanidin biosynthesis during apricot fruit development"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2576-3246","authenticated-orcid":false,"given":"Xu","family":"Qiang","sequence":"first","affiliation":[{"name":"Xi'an Botanical Garden of Shaanxi Province (Institute of Botany of Shaanxi Province)  Xi'an Shaanxi 710061 China"},{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education) College of Life Sciences Northwest University  Xi'an Shaanxi 710069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou Gansu 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Environment and Life Sciences Weinan Normal University  Weinan Shaanxi 714099 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ren","sequence":"additional","affiliation":[{"name":"Xi'an Botanical Garden of Shaanxi Province (Institute of Botany of Shaanxi Province)  Xi'an Shaanxi 710061 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0599-8589","authenticated-orcid":false,"given":"Yun","family":"Jia","sequence":"additional","affiliation":[{"name":"Xi'an Botanical Garden of Shaanxi Province (Institute of Botany of Shaanxi Province)  Xi'an Shaanxi 710061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-5586","authenticated-orcid":false,"given":"Zhonghu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education) College of Life Sciences Northwest University  Xi'an Shaanxi 710069 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-1126","authenticated-orcid":false,"given":"Ming","family":"Yue","sequence":"additional","affiliation":[{"name":"Xi'an Botanical Garden of Shaanxi Province (Institute of Botany of 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