{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:35:03Z","timestamp":1791153303361,"version":"4.1.0"},"reference-count":139,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    <jats:bold>Dengue is the most common arthropod\u2010borne viral infection in humans with \u223c50 million cases annually worldwide. In recent decades, a steady increase in the number of severe dengue cases has been seen. Severe dengue disease is most often observed in individuals that have pre\u2010existing immunity against heterotypic dengue subtypes and in infants with low levels of maternal dengue antibodies. The generally accepted hypothesis explaining the immunopathogenesis of severe dengue is called antibody\u2010dependent enhancement of dengue infection. Here, circulating antibodies bind to the newly infecting virus but do not neutralize infection. Rather, these antibodies increase the infected cell mass and virus production. Additionally, antiviral responses are diminished allowing massive virus particle production early in infection. The large infected cell mass and the high viral load are prelude for severe disease development. In this review, we discuss what is known about the trafficking of dengue virus in its human host cells, and the signalling pathways activated after virus detection, both in the absence and presence of antibodies against the virus. This review summarizes work that aims to better understand the complex immunopathogenesis of severe dengue disease.<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12012-gra-0001.gif\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1111\/tra.12012","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T14:15:09Z","timestamp":1348236909000},"page":"25-35","source":"Crossref","is-referenced-by-count":115,"title":["Molecular Mechanisms Involved in Antibody\u2010Dependent Enhancement of Dengue Virus Infection in Humans"],"prefix":"10.1111","volume":"14","author":[{"given":"Jacky","family":"Flipse","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Molecular Virology Section University Medical Center Groningen, University of Groningen  Groningen The 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