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They share a core of subunits that can activate the\n                    <jats:styled-content style=\"fixed-case\">GTPase<\/jats:styled-content>\n                    Rab1 through a guanine nucleotide exchange factor (\n                    <jats:styled-content style=\"fixed-case\">GEF<\/jats:styled-content>\n                    ) activity and are distinguished by \u2018accessory\u2019 subunits giving each complex its distinct function. The subunits are ubiquitously expressed and, thus, mutations in\n                    <jats:styled-content style=\"fixed-case\">TRAPP<\/jats:styled-content>\n                    subunits would be expected to be embryonic lethal. However, since its discovery, a number of subunits have been found to be mutated in several diverse human disorders suggesting that some of these subunits may have cell\u2010 or tissue\u2010specific functions. Here we review the current state of knowledge with respect to\n                    <jats:styled-content style=\"fixed-case\">TRAPP<\/jats:styled-content>\n                    subunit mutations in human disease. We suggest ideas to explain their tissue\u2010specific phenotypes and present avenues for future investigation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12183-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1111\/tra.12183","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T18:28:38Z","timestamp":1402424918000},"page":"803-818","source":"Crossref","is-referenced-by-count":49,"title":["In Sickness and in Health: The Role of\n                    <scp>TRAPP<\/scp>\n                    and Associated Proteins in Disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Stephanie","family":"Brunet","sequence":"first","affiliation":[{"name":"Department of Biology Concordia University  7141 Sherbrooke Street West, SP\u2010457.01 Montreal QC H4B 1R6 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