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These cognitive changes may reflect the effects of drugs of abuse on prefrontal cortical neurobiology. Here, we review evidence that amphetamine and cocaine fundamentally remodel the structure of excitatory neurons in the prefrontal cortex. We summarize evidence in particular that these psychostimulants have opposing effects in the medial and orbital prefrontal cortices (\u2018\n                    <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content>\n                    \u2019 and \u2018\n                    <jats:styled-content style=\"fixed-case\">oPFC<\/jats:styled-content>\n                    \u2019, respectively). For example, amphetamine and cocaine increase dendrite length and spine density in the\n                    <jats:styled-content style=\"fixed-case\">mPFC<\/jats:styled-content>\n                    , while dendrites are impoverished and dendritic spines are eliminated in the\n                    <jats:styled-content style=\"fixed-case\">oPFC<\/jats:styled-content>\n                    . We will discuss evidence that certain cytoskeletal regulatory proteins expressed in the\n                    <jats:styled-content style=\"fixed-case\">oPFC<\/jats:styled-content>\n                    and implicated in postnatal (adolescent) neural development also regulate behavioral sensitivity to cocaine. These findings potentially open a window of opportunity for the identification of novel pharmacotherapeutic targets in the treatment of drug abuse disorders in adults, as well as in drug\u2010vulnerable adolescent populations. Finally, we will discuss the behavioral implications of drug\u2010related dendritic spine elimination in the\n                    <jats:styled-content style=\"fixed-case\">oPFC<\/jats:styled-content>\n                    , with regard to reversal learning tasks and tasks that assess the development of reward\u2010seeking habits, both used to model aspects of addiction in rodents.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12295-gra-0001.png\" xlink:title=\"image\"\/>\n                  <\/jats:p>","DOI":"10.1111\/tra.12295","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T13:06:49Z","timestamp":1431004009000},"page":"919-940","source":"Crossref","is-referenced-by-count":48,"title":["Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure"],"prefix":"10.1111","volume":"16","author":[{"given":"Lauren M.","family":"DePoy","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine Atlanta GA USA"},{"name":"Department of Psychiatry Emory University School of Medicine Atlanta GA USA"},{"name":"Yerkes National Primate Research Center Emory University Atlanta GA USA"},{"name":"Graduate Program in Neuroscience Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Gourley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine Atlanta GA USA"},{"name":"Department of Psychiatry Emory University School of Medicine Atlanta GA USA"},{"name":"Yerkes National Primate Research Center Emory University Atlanta GA USA"},{"name":"Graduate Program in Neuroscience Emory University Atlanta GA 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