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Neuronal growth factor signaling is highly dependent on membrane traffic, both for the packaging and release of the growth factors themselves, and for regulation of intracellular signaling by their transmembrane receptors. Here, we review recent findings from the <jats:italic>Drosophila<\/jats:italic> larval neuromuscular junction (<jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content>) that illustrate how specific steps of intracellular traffic and inter\u2010organelle interactions impinge on signaling, particularly in the bone morphogenic protein, Wingless and c\u2010Jun\u2010activated kinase pathways, regulating elaboration and stability of <jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content> arbors, construction of synapses and synaptic transmission and homeostasis. These membrane trafficking and signaling pathways have been implicated in human motor neuron diseases including amyotrophic lateral sclerosis and hereditary spastic paraplegia, highlighting their importance for neuronal health and survival.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12345-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1111\/tra.12345","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T09:08:44Z","timestamp":1446714524000},"page":"87-101","source":"Crossref","is-referenced-by-count":48,"title":["The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from <i>Drosophila<\/i>"],"prefix":"10.1111","volume":"17","author":[{"given":"Mugdha","family":"Deshpande","sequence":"first","affiliation":[{"name":"Department of Biology Brandeis University  Waltham MA 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