{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:28:09Z","timestamp":1791343689419,"version":"4.3.1"},"reference-count":111,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI119159"],"award-info":[{"award-number":["AI119159"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Herpesviral pathogenesis stems from infection of multiple cell types including the site of latency and cells that support lytic replication. Herpesviruses utilize distinct cellular pathways, including low <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> endocytic pathways, to enter different pathophysiologically relevant target cells. This review details the impact of the mildly acidic milieu of endosomes on the entry of herpesviruses, with particular emphasis on herpes simplex virus 1 (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101). Epithelial cells, the portal of primary <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101 infection, support entry via low <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> endocytosis mechanisms. Mildly acidic <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> triggers reversible conformational changes in the <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101 class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> fusion protein glycoprotein B (<jats:styled-content style=\"fixed-case\">gB<\/jats:styled-content>). <jats:italic>In vitro<\/jats:italic> treatment of herpes simplex virions with a similar <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> range inactivates infectivity, likely by prematurely activating the viral entry machinery in the absence of a target membrane. How a given herpesvirus mediates both low <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010independent entry events is a key unresolved question.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12408-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1111\/tra.12408","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T14:25:30Z","timestamp":1462026330000},"page":"965-975","source":"Crossref","is-referenced-by-count":100,"title":["Herpesvirus Entry into Host Cells Mediated by Endosomal Low <scp>pH<\/scp>"],"prefix":"10.1111","volume":"17","author":[{"given":"Anthony V.","family":"Nicola","sequence":"first","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine Washington State University  Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016972"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1456"},{"key":"e_1_2_15_4_1","first-page":"1823","volume-title":"Fields Virology","author":"Roizman B","year":"2013"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.005"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080106"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00007.2013"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-177"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.84.2.404"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1983.tb07841.x"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.37.110"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.21.7972"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31546-6"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7651-1_10"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.12.001"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2548"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113799"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1618"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9992-10002.1998"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.3.539"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81363-X"},{"key":"e_1_2_15_22_1","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1128\/jvi.62.8.2596-2604.1988","article-title":"Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion","volume":"62","author":"Cai WH","year":"1988","journal-title":"J Virol"},{"key":"e_1_2_15_23_1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/jvi.62.5.1486-1494.1988","article-title":"A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta\u2010galactosidase sequences binds to but is unable to penetrate into cells","volume":"62","author":"Ligas MW","year":"1988","journal-title":"J Virol"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.1.341-348.1992"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.4.2285-2297.1993"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7508-7517.2004"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.2.834-845.1994"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.1.873-875.1998"},{"key":"e_1_2_15_29_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/jvi.2.5.507-516.1968","article-title":"Electron microscopy of herpes simplex virus. 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